Brain structural MRI correlates of cognitive dysfunctions in Parkinson's disease
Brain structural MRI correlates of cognitive dysfunctions in Parkinson's disease
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DOI：
10.1016/j.jns.2011.07.054
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发表时间：
2011-11-15
影响因子：
4.4
通讯作者：
Tolosa, Eduardo
中科院分区：
文献类型：
--
作者：
Ibarretxe-Bilbao, Naroa;Junque, Carme;Tolosa, Eduardo
认知功能障碍发生在帕金森病(PD)的早期阶段。初步研究报告，早期帕金森病患者的认知功能障碍只影响额叶-纹状体回路，导致明显的执行功能障碍。帕金森病的记忆障碍被认为依赖于提取存储信息的问题，因此也反映了额叶-纹状体功能障碍。然而，越来越多的结构MRI证据表明帕金森病患者的内侧颞叶萎缩，这可能与记忆功能障碍有关。帕金森病患者的其他神经心理功能通常受损，包括语义流畅性、视觉知觉和视觉空间功能、面部情绪的决策和识别；这些功能的损害与MRI评估的皮质结构变化有关。总体而言，尽管关于这一主题的文献很少，但越来越多的证据表明，大脑结构发生了变化，可以通过核磁共振检测到，这可以解释痴呆发生之前临床病程早期的神经心理缺陷。在这篇综述中，我们总结了利用结构磁共振研究帕金森病认知功能障碍的神经解剖学相关性的文献。(C)2011爱思唯尔B.V.保留所有权利。
Cognitive dysfunction occurs at early stages of Parkinson's disease (PD). Initial studies reported that cognitive dysfunction in early PD only affected fronto-striatal circuits, provoking a marked executive dysfunction. Memory impairment in PD was thought to depend on a problem in retrieving stored information, therefore also reflecting a fronto-striatal dysfunction. However, there is increasing structural MRI evidence of medial temporal lobe atrophy in PD, which may be responsible for memory dysfunction. Other neuropsychological functions usually impaired in PD are semantic fluency, visuoperceptual and visuospatial functions, decision-making and recognition of facial emotions; and impairments in these functions are associated with cortical structural changes assessed by MRI. Overall, although the literature on the topic is scarce, there is increasing evidence of brain structural changes, detectable by MRI, which can explain the neuropsychological deficits early in the clinical disease course before dementia develops. In this review, we summarize the papers that have used structural MRI to study the neuroanatomical correlates of cognitive dysfunctions in PD. (C) 2011 Elsevier B.V. All rights reserved.