Special delivery: granulin brings CpG DNA to Toll-like receptor 9.
Special delivery: granulin brings CpG DNA to Toll-like receptor 9.
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特别递送:颗粒蛋白将 CpG DNA 带到 Toll 样受体 9。
DOI:
10.1016/j.immuni.2011.04.001
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发表时间:
2011
期刊:
影响因子:
32.4
通讯作者:
Beutler,Bruce
中科院分区:
文献类型:
--
作者:
Moresco,EvaMarieY;Beutler,Bruce
Foreign DNA activates the innate immune response through Toll-like receptor 9 (TLR9). In this issue ofImmunity, Park et al. (2011) present evidence that granulin is a cofactor for TLR9 activation, delivering CpG-oligodeoxynucleotides to TLR9 in endolysosomes.