Vitamin A regulates obesity in WNIN/Ob obese rat; independent of stearoyl-CoA desaturase-1
Vitamin A regulates obesity in WNIN/Ob obese rat; independent of stearoyl-CoA desaturase-1
复制标题
DOI：
10.1016/j.bbrc.2008.03.073
复制
发表时间：
2008-05-30
影响因子：
3.1
通讯作者：
Giridharan, N. V.
中科院分区：
文献类型：
--
作者：
Jeyakumar, S. M.;Vajreswari, A.;Giridharan, N. V.
硬脂酰辅酶A去饱和酶1（stearoyl-CoA desaturase 1，SCD 1）是单不饱和脂肪酸生物合成中的重要酶，在能量平衡中起着重要作用。在这里，我们测试了维生素A对肝脏和脂肪组织SCD 1表达和肥胖本身的影响，使用肥胖突变大鼠品系，即WNIN/Ob，在印度国家营养研究所国家实验动物科学中心开发。将7月龄的24只WNIN/Ob品系雄性瘦和肥胖大鼠分为两组;每组再分为两个亚组，其中6只瘦大鼠和6只肥胖大鼠，并接受含有2.6 mg或129 mg维生素A/kg饮食的饮食两个月。喂食高剂量（但无毒）维生素A导致肥胖大鼠体重增加和腹膜后白色脂肪组织重量（RPWAT）显著减少。此外，维生素A喂养导致SCD 1在瘦大鼠的肝脏和RPWAT中的表达增加，而在肥胖大鼠中没有观察到这种作用。综上所述，目前的数据表明，维生素A在肥胖大鼠模型中独立于SCD 1基因调控而降低体重增加。(C)2008年爱思唯尔公司All rights reserved.
Stearoyl-CoA desaturase 1 (SCD1), an important enzyme involved in monounsaturated fatty acid biosynthesis is a key player in energy homeostasis. Here, we tested the impact of vitamin A on hepatic and adipose tissue SCD1 expression and adiposity per se, using an obese mutant rat strain namely, WNIN/Ob developed at National Center for Laboratory Animal Sciences of National Institute of Nutrition, India. Seven months-old 24 mate lean and obese rats of WNIN/Ob strain were divided into two groups; each group was subdivided into two subgroups having 6 lean and 6 obese rats and received diets containing either 2.6 mg or 129 mg vitamin A/kg diet for two months. Feeding of high (but non-toxic) doses of vitamin A resulted in significant reduction in body weight gain, and retroperitoneal white adipose tissue weight (RPWAT) in obese rats. Further, vitamin A feeding resulted in augmented expression of SCD1 in liver and RPWAT of lean rats, while no such effect was seen in obese rats. Taken together, the present data suggest that vitamin A decreases body weight gain in obese rat model independent of SCD1 gene regulation. (C) 2008 Elsevier Inc. All rights reserved.