Mitochondrial Contributions to Hematopoietic Stem Cell Aging.
Mitochondrial Contributions to Hematopoietic Stem Cell Aging.
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DOI：
10.3390/ijms222011117
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发表时间：
2021-10-15
影响因子：
5.6
通讯作者：
Ito K
中科院分区：
文献类型：
--
作者：
Morganti C;Ito K
线粒体功能障碍和干细胞衰竭是衰老的两个标志。在造血系统中，衰老与不平衡的免疫反应和造血干细胞（HSC）再生能力降低有关，以及对一系列疾病的易感性增加，包括骨髓增生异常综合征和急性髓性白血病。骨髓偏向性分化和极性丧失是老化HSC的独特特征，其通常表现出增强的线粒体氧化磷酸化和增加的活性氧（ROS）产生，表明线粒体在退行性过程中的直接作用。在这里，我们提供了一个概述的线粒体机制，有助于年龄相关的表型造血干细胞的当前知识。这些包括线粒体ROS产生、线粒体代谢的改变/激活、线粒体的质量控制途径和炎症。对HSC衰老的关键机制的更深入了解将使我们能够确定新的治疗靶点，以预防，延迟甚至逆转这一过程的各个方面。
Mitochondrial dysfunction and stem cell exhaustion are two hallmarks of aging. In the hematopoietic system, aging is linked to imbalanced immune response and reduced regenerative capacity in hematopoietic stem cells (HSCs), as well as an increased predisposition to a spectrum of diseases, including myelodysplastic syndrome and acute myeloid leukemia. Myeloid-biased differentiation and loss of polarity are distinct features of aged HSCs, which generally exhibit enhanced mitochondrial oxidative phosphorylation and increased production of reactive oxygen species (ROS), suggesting a direct role for mitochondria in the degenerative process. Here, we provide an overview of current knowledge of the mitochondrial mechanisms that contribute to age-related phenotypes in HSCs. These include mitochondrial ROS production, alteration/activation of mitochondrial metabolism, the quality control pathway of mitochondria, and inflammation. Greater understanding of the key machineries of HSC aging will allow us to identify new therapeutic targets for preventing, delaying, or even reversing aspects of this process.
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影响因子：
8.8
作者：
Brown K;Xie S;Qiu X;Mohrin M;Shin J;Liu Y;Zhang D;Scadden DT;Chen D
通讯作者：
Chen D
在健康个体中预测急性髓样白血病的风险。
影响因子：
64.8
作者：
Abelson S;Collord G;Ng SWK;Weissbrod O;Mendelson Cohen N;Niemeyer E;Barda N;Zuzarte PC;Heisler L;Sundaravadanam Y;Luben R;Hayat S;Wang TT;Zhao Z;Cirlan I;Pugh TJ;Soave D;Ng K;Latimer C;Hardy C;Raine K;Jones D;Hoult D;Britten A;McPherson JD;Johansson M;Mbabaali F;Eagles J;Miller JK;Pasternack D;Timms L;Krzyzanowski P;Awadalla P;Costa R;Segal E;Bratman SV;Beer P;Behjati S;Martincorena I;Wang JCY;Bowles KM;Quirós JR;Karakatsani A;La Vecchia C;Trichopoulou A;Salamanca-Fernández E;Huerta JM;Barricarte A;Travis RC;Tumino R;Masala G;Boeing H;Panico S;Kaaks R;Krämer A;Sieri S;Riboli E;Vineis P;Foll M;McKay J;Polidoro S;Sala N;Khaw KT;Vermeulen R;Campbell PJ;Papaemmanuil E;Minden MD;Tanay A;Balicer RD;Wareham NJ;Gerstung M;Dick JE;Brennan P;Vassiliou GS;Shlush LI
通讯作者：
Shlush LI
影响因子：
82.9
作者：
Chen, Jiahao;Kao, Yun-Ruei;Steidl, Ulrich
通讯作者：
Steidl, Ulrich
DOI：
10.1084/jem.20081297
发表时间：
2008-09-29
期刊：
The Journal of experimental medicine
影响因子：
--
作者：
Chen C;Liu Y;Liu R;Ikenoue T;Guan KL;Liu Y;Zheng P
通讯作者：
Zheng P
影响因子：
29
作者：
Ahlqvist, Kati J.;Hamalainen, Riikka H.;Suomalainen, Anu
通讯作者：
Suomalainen, Anu