Sluggish Cognitive Tempo in Pediatric Sickle Cell Disease.
Sluggish Cognitive Tempo in Pediatric Sickle Cell Disease.
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DOI：
10.3389/fneur.2022.867437
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发表时间：
2022
影响因子：
3.4
通讯作者：
Schatz, Jeffrey
中科院分区：
文献类型：
--
作者：
Hardy, Steven J.;Forman, Sydney;Hardy, Kristina K.;Schatz, Jeffrey
镰状细胞病(SCD)具有一系列神经发育和神经认知障碍的风险。认知节奏迟缓(SCT)是一种独特的综合征，常与注意力缺陷/多动障碍(ADHD)并存，但在SCD中尚未被描述。我们调查了SCT测量在SCD中的可靠性和有效性，并检查了与生物、心理、社会风险因素和功能结果的相关性。85名7-16岁SCD儿童的照顾者报告了社会人口学和儿童迟滞认知节奏(K-SCT)测量、执行功能行为评定量表和Conners 3。疾病相关特征从健康记录中提取。K-SCT具有良好的内部一致性(α=0.92)和重测信度(r=0.82，p<；0.001)。K-SCT评分与注意缺陷多动障碍(r=0.64，p<；0.001)、多动/冲动多动障碍(r=0.46，p<；0.001)以及包括学习问题在内的功能结果(r=0.69，p<；0.001)呈正相关。在控制ADHD症状的多变量分析中，SCT在学习(b=9.67，p<；0.01)和执行功能(b=5.93，p<；0.01)方面解释了唯一的差异。几乎所有(93%)同时出现SCT和ADHD注意力不集中症状的参与者(93%)都有明显的学习问题。K-SCT是SCD中SCT的一种可靠有效的测量方法。即使在控制了ADHD症状之后，SCT症状也与学习困难有关。需要进一步的研究来了解导致SCD中SCT症状的生物、心理和社会因素，并检查SCT的长期影响。
Sickle cell disease (SCD) imparts risk for a range of neurodevelopmental and neurocognitive disorders. Sluggish cognitive tempo (SCT) is a distinct syndrome that often co-occurs with attention-deficit/hyperactivity disorder (ADHD) but has not been described in SCD. We investigated the reliability and validity of a SCT measure in SCD and examined associations with biopsychosocial risk factors and functional outcomes. Caregivers (n = 85) of children with SCD ages 7-16 reported on socio-demographics and the Kiddie-Sluggish Cognitive Tempo (K-SCT) measure, Behavior Rating Inventory of Executive Function, and Conners 3. Disease-related characteristics were extracted from health records. The K-SCT demonstrated excellent internal consistency (α = 0.92) and test-retest reliability (r = 0.82, p < 0.001). K-SCT scores were correlated with ADHD-Inattention (r = 0.64, p < 0.001) and ADHD-Hyperactive/Impulsive (r = 0.46, p < 0.001) scores, as well as functional outcomes, including learning problems (r = 0.69, p < 0.001). In multivariate analyses controlling for ADHD symptoms, SCT accounted for unique variance in learning (b = 9.67, p < 0.01) and executive functioning (b = 5.93, p < 0.01). Nearly all participants (93%) with elevated levels of co-occurring SCT and ADHD-Inattention symptoms had significant learning problems. The K-SCT is a reliable and valid measure of SCT in SCD. SCT symptoms are associated with learning difficulties even after controlling for ADHD symptoms. Further research is needed to understand the biopsychosocial factors that lead to SCT symptoms in SCD and examine long-term implications of SCT.
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影响因子：
1.6
作者：
Lance EI;Comi AM;Johnston MV;Casella JF;Shapiro BK
通讯作者：
Shapiro BK
影响因子：
1.2
作者：
Acquazzino, Melissa A.;Miller, Meghan;Scott, John Paul
通讯作者：
Scott, John Paul
DOI：
10.1097/dbp.0000000000000914
发表时间：
2021-08-01
期刊：
Journal of developmental and behavioral pediatrics : JDBP
影响因子：
--
作者：
Lance EI;Cannon AD;Shapiro BK;Lee LC;Johnston MV;Casella JF
通讯作者：
Casella JF
影响因子：
2.2
作者：
Bills, Sarah E.;Schatz, Jeffrey;Reinman, Laura
通讯作者：
Reinman, Laura
DOI：
10.1097/dbp.0b013e31824ba1b5
发表时间：
2012-04-01
影响因子：
2.4
作者：
Daly, Brian;Kral, Mary C.;Jackson, Sherron
通讯作者：
Jackson, Sherron