Hormone Action in the Mammary Gland
Hormone Action in the Mammary Gland
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DOI：
10.1101/cshperspect.a003178
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发表时间：
2010-12-01
影响因子：
7.2
通讯作者：
O'Malley, Bert
中科院分区：
文献类型：
--
作者：
Brisken, Cathrin;O'Malley, Bert
女性患乳腺癌的风险受其生育史的影响。激素环境也影响疾病的进程。女性生殖激素，雌激素，孕激素和催乳素，对乳腺癌有重要影响，并控制产后乳腺发育。结合组织重组技术和蛋白质组学的激素受体突变小鼠品系的分析表明，乳腺上皮中激素信号的顺序激活是形态发生进展所必需的。激素作用于表达激素受体的乳腺腔上皮细胞（MEC）的亚群，并作为传感器细胞将系统信号翻译和放大为局部刺激。增殖是由旁分泌机制诱导的，在不同的阶段由不同的因子介导。激素信号的组织和阶段特异性在分子水平上通过不同的染色质背景和辅激活子和辅抑制子的差异募集来实现。
A woman's breast cancer risk is affected by her reproductive history. The hormonal milieu also influences the course of the disease. The female reproductive hormones, estrogens, progesterone, and prolactin, have a major impact on breast cancer and control postnatal mammary gland development. Analysis of hormone receptor mutant mouse strains combined with tissue recombination techniques and proteomics revealed that sequential activation of hormone signaling in the mammary epithelium is required for progression of morphogenesis. Hormones impinge on a subset of luminal mammary epithelial cells (MECs) that express hormone receptors and act as sensor cells translating and amplifying systemic signals into local stimuli. Proliferation is induced by paracrine mechanisms mediated by distinct factors at different stages. Tissue and stage specificity of hormonal signaling is achieved at the molecular level by different chromatin contexts and differential recruitment of coactivators and corepressors.