Mechanical Regulation of Nuclear Translocation in Migratory Neurons
Mechanical Regulation of Nuclear Translocation in Migratory Neurons
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DOI：
10.3389/fcell.2020.00150
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发表时间：
2020-03
影响因子：
5.5
通讯作者：
Naotaka Nakazawa;M. Kengaku
中科院分区：
文献类型：
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作者：
Naotaka Nakazawa;M. Kengaku
神经元迁移是脑内功能性神经回路形成的关键步骤。新生的神经元需要从生发区跨越很长的距离移动到它们各自的功能部位;在它们的迁移过程中，它们必须经常挤压它们大而坚硬的核，克服强大的机械应力，穿过发育中的脑组织中的狭窄空间。最近的研究阐明了肌动球蛋白和微管马达如何在特定的亚细胞区室产生机械力，并协同驱动神经元的核转位。另一方面，周围组织的机械性质也有助于它们作为细胞骨架力传递的粘附支持的功能，同时它们也作为核转位的物理屏障。在这篇综述中，我们讨论了最近的研究在发育中的神经元核迁移，从细胞和机械生物学的观点。
Neuronal migration is a critical step during the formation of functional neural circuits in the brain. Newborn neurons need to move across long distances from the germinal zone to their individual sites of function; during their migration, they must often squeeze their large, stiff nuclei, against strong mechanical stresses, through narrow spaces in developing brain tissue. Recent studies have clarified how actomyosin and microtubule motors generate mechanical forces in specific subcellular compartments and synergistically drive nuclear translocation in neurons. On the other hand, the mechanical properties of the surrounding tissues also contribute to their function as an adhesive support for cytoskeletal force transmission, while they also serve as a physical barrier to nuclear translocation. In this review, we discuss recent studies on nuclear migration in developing neurons, from both cell and mechanobiological viewpoints.