Effect of Atropine on Rat Basal Pancreatic Secretion during Return or Diversion of Bile-Pancreatic Juice
Effect of Atropine on Rat Basal Pancreatic Secretion during Return or Diversion of Bile-Pancreatic Juice
复制标题
阿托品对胆胰液回流或分流过程中大鼠基础胰腺分泌的影响
DOI：
10.3181/00379727-174-41723
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发表时间：
1983
影响因子：
--
通讯作者：
G. Green
中科院分区：
文献类型：
--
作者：
K. Miyasaka;G. Green
本文观察了清醒大鼠胆胰液（BPJ）回流和不回流时阿托品对胰腺基础外分泌的影响。大鼠分别用套管引流胆汁和胰液，并用十二指肠套管回流分泌物。实验在术后3天开始。在胆胰分泌持续回流期间，静脉注射阿托品（100 μg/kg·hr）可持续抑制胰腺蛋白分泌80-90%，对胰液量的抑制作用则小得多。胆胰液从肠道分流显着增加胰腺蛋白质和液体分泌的控制和阿托品输注大鼠，但反应显着抑制阿托品（体积抑制31%，蛋白质输出41%的抑制）。结果表明，在返回的BPJ的基础胰腺蛋白分泌主要是由胆碱能的影响，可能是由于肠胰反射，并抑制胰腺反应急性转移的BPJ阿托品可能是次要的抑制胃液分泌。
Abstract The effect of atropine on basal pancreatic exocrine secretion in conscious rats was determined with and without return of bile–pancreatic juice (BPJ) to the intestine. Rats were prepared with cannulas draining bile and pancreatic juice separately and with duodenal cannulas for return of secretions. Experiments were begun 3 days postoperatively. During continuous return of bile-pancreatic secretions, intravenous atropine (100 μg/kg-hr) caused a sustained 80–90% inhibition of pancreatic protein secretion, with a much smaller suppressive effect on pancreatic juice volume. Diversion of bile-pancreatic juice from the intestine markedly increased pancreatic protein and fluid secretion in control and atropine-infused rats, but the response was significantly inhibited by atropine (volume 31% inhibition, protein output 41% inhibition). The results indicate that basal pancreatic protein secretion during return of BPJ is largely maintained by cholinergic influence, possibly due to an enteropancreatic reflex, and that the inhibition of the pancreatic response to acute diversion of BPJ by atropine is probably secondary to inhibition of gastric secretion.