Basal cell carcinomas developing in solid organ transplant recipients - Clinicopathologic study of 176 cases
Basal cell carcinomas developing in solid organ transplant recipients - Clinicopathologic study of 176 cases
复制标题
DOI：
10.1001/archderm.139.9.1133
复制
发表时间：
2003-09-01
影响因子：
--
通讯作者：
Claudy, A
中科院分区：
文献类型：
--
作者：
Kanitakis, J;Alhaj-Ibrahim, L;Claudy, A
目的：评估发展中的器官移植recipients.Design的基底细胞癌的临床病理特征：病例系列。设置：大学部皮肤病患者：一百四十六（7.2%）的2029移植受者在我们的部门谁开发176个组织学证实的基底细胞癌。从nonimmunosuppressed patients切除的基底细胞癌随机样本153作为controls.Main结果措施：临床数据收集的医疗记录。组织切片进行回顾性reexamined.Results：基底细胞癌平均6.9年移植后，心脏移植后比肾移植，并表现出相对的偏好心脏移植受体。基底细胞癌移植受者的平均年龄显著低于对照组（54.6 vs 69.8岁），尤其是肾移植受者，男性占优势（男女比例为4.8：1 vs 1.3：1）。在两组中，基底细胞癌主要发生在头部和颈部，但脑外部位在移植受者（37.5%）中的发生率明显高于对照组（24.5%）。组织学上，浅表基底细胞癌在移植受者中比对照组更常见（33.6%对14.4%）。与对照组相比，移植受者的肿瘤中瘤周细胞浸润的密度较低。肿瘤厚度和表皮溃疡的存在并没有显着差异2 groups.Conclusions：基底细胞癌移植受者表现出一些临床病理差异，从他们的“普通”的同行，即，一个年轻的发展年龄，男性优势，更频繁的分布在脑外部位，和更高的频率浅表亚型。
Objective: To assess the clinicopathologic features of basal cell carcinomas developing in organ transplant recipients.Design: Case series.Setting: University department of dermatologyPatients: One hundred forty-six (7.2%) of 2029 transplant recipients followed up in our department who developed 176 histologically proven basal cell carcinomas. One hundred fifty-three random samples of basal cell carcinomas excised from nonimmunosuppressed patients served as controls.Main Outcome Measures: Clinical data were gathered from the medical records. Histologic slides were retrospectively reexamined.Results: Basal cell carcinomas developed an average of 6.9 years after transplantation, sooner after heart than kidney transplantation, and showed a relative predilection for heart allograft recipients. The mean age of transplant recipients with basal cell carcinomas was significantly lower than that of controls (54.6 vs 69.8 years), especially for recipients of renal transplants, and a male preponderance was found (male-female ratio, 4.8:1 vs 1.3:1). In both groups, basal cell carcinomas were predominantly found on the head and neck, but extracephalic locations were significantly more frequent in transplant recipients (37.5%) than controls (24.5%). Histologically, superficial basal cell carcinomas were more frequent in transplant recipients than controls (33.6% vs 14.4%). The density of the peritumoral cell infiltrate was lower in tumors from transplant recipients compared with controls. The tumor thickness and the presence of epidermal ulceration did not differ significantly between the 2 groups.Conclusions: Basal cell carcinomas in transplant recipients show some clinicopathologic differences from their "ordinary" counterparts, namely, a younger age at development, male preponderance, more frequent distribution in extracephalic sites, and higher frequency of superficial subtypes.