Ain't misbehavin? Genotype-environment interactions and the genetics of behavior
Ain't misbehavin? Genotype-environment interactions and the genetics of behavior
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DOI：
10.1016/j.tig.2007.03.013
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发表时间：
2007-07-01
影响因子：
11.4
通讯作者：
Anholt, Robert R. H.
中科院分区：
文献类型：
--
作者：
Mackay, Trudy F. C.;Anholt, Robert R. H.
虽然影响复杂性状的多个相互作用的基因可以很容易地被解剖，但基因型-环境相互作用对复杂性状的变异有多大贡献仍然是难以捉摸的。最近的一项研究量化了几十年来不同实验室中相同小鼠品系的几种行为表型，表明实验室之间的一些行为差异仍然具有很大的可复制性，而另一些则随着时间的推移而不那么稳定。这份报告，以及果蝇的研究，强调了理解基因型与环境相互作用的重要性。
Although the multiple interacting genes affecting complex traits can readily be dissected, how much genotype-environment interactions contribute to variation in complex traits remains elusive. A recent study that quantified several behavioral phenotypes on the same mouse strains in different laboratories decades apart, shows that some behavioral differences between laboratories remain greatly replicable, whereas others are less robust over time. This report, together with studies from Drosophila, stresses the importance of understanding genotype-environment interactions.