A complex flow pattern of low shear stress and flow reversal promotes monocyte binding to endothelial cells
A complex flow pattern of low shear stress and flow reversal promotes monocyte binding to endothelial cells
复制标题
DOI：
10.1016/s0021-9150(01)00462-2
复制
发表时间：
2001-10-01
期刊：
影响因子：
5.3
通讯作者：
Demer, LL
中科院分区：
文献类型：
--
作者：
Honda, HM;Hsiai, T;Demer, LL
血管内动脉粥样硬化的好发部位的特征是低切应力和流动逆转。在这项研究中，内皮细胞暴露于一个复杂的流动模式，其特征在于颗粒速度测定。与暴露于单向流动的内皮细胞相比，暴露于低剪切应力和流动逆转的牛主动脉内皮细胞表现出更高水平的单核细胞结合。此外，内皮细胞暴露于低剪切应力和流动逆转的炎症刺激与单核细胞结合大幅增加，类似于细胞暴露于单向流动。这些发现提示了一种机制，即低切应力和血流逆转区易发生动脉粥样硬化病变。(C)2001爱思唯尔科学爱尔兰有限公司保留所有权利。
Predilection sites for atherosclerosis within the vasculature are characterized by low shear stress and flow reversal. In this study, endothelial cells were exposed to a complex flow pattern that was characterized by particle velocity determination. Bovine aortic endothelial cells exposed to low shear stress and flow reversal demonstrated higher levels of monocyte binding compared to endothelial cells exposed to one-directional flow. In addition, endothelial cells exposed to low shear stress and flow reversal responded to inflammatory stimuli with substantial increases in monocyte binding, similar to that seen in cells exposed to one-directional flow. These findings suggest a mechanism by which areas of low shear stress and flow reversal are predisposed to the development of atherosclerotic lesions. (C) 2001 Elsevier Science Ireland Ltd. All rights reserved.