Near-Infrared and Visible Photoactivation to Uncage Carbon Monoxide from an Aqueous-Soluble PhotoCORM
Near-Infrared and Visible Photoactivation to Uncage Carbon Monoxide from an Aqueous-Soluble PhotoCORM
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DOI：
10.1021/acs.inorgchem.9b01581
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发表时间：
2019-08-19
影响因子：
4.6
通讯作者：
Ford, Peter C.
中科院分区：
文献类型：
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作者：
Jiang, Qin;Xia, Yingzi;Ford, Peter C.
多光子激发允许人们利用组织穿透近红外 (NIR) 光进入高能激发态并在生物系统中执行有价值的任务。在这里，我们描述了新的光活性三羰基锰络合物，其中包含配体 4'-p-N,N-双(2-羟乙基)氨基-苄基-2,2':6',2''-三联吡啶 (TPYOH)，它可以作为双光子近红外激发的天线。 Mn(CO)(3)(TPYOH)X（X = Br- 或 CF3SO3-）络合物溶液在可见光激发（405 nm、451 nm）下对 CO 释放具有很强的光活性。 750 和 800 nm 的多光子激发也引发了相同的反应。在这种情况下，我们讨论了这些复合物作为可见光/近红外光光活化一氧化碳释放部分（photoCORM）的潜在应用。我们还报告了 TPYOH 配合物 Mn(TPYOH)Cl-2 和 [Mn(TPYOH)(2)](CF3SO3)(2) 的分离和晶体结构，以说明可能的光解产物。
Multiphoton excitation allows one to access high energy excited states and perform valuable tasks in biological systems using tissue penetrating near-infrared (NIR) light. Here, we describe new photoactive manganese tricarbonyl complexes incorporating the ligand 4'-p-N,N-bis(2-hydroxyethyl)amino-benzyl-2,2':6',2 ''-terpyridine (TPYOH), which can serve as an antenna for two photon NIR excitation. Solutions of Mn(CO)(3)(TPYOH)X (X = Br- or CF3SO3-) complexes are very photoactive toward CO release under visible light excitation (405 nm, 451 nm). The same responses were also triggered by multiphoton excitation at 750 and 800 nm. In this context, we discuss the potential applications of these complexes as visible/NIR light photoactivated carbon monoxide releasing moieties (photoCORMs). We also report the isolation and crystal structures of the TPYOH complexes Mn(TPYOH)Cl-2 and [Mn(TPYOH)(2)](CF3SO3)(2), to illustrate a possible photolysis product(s).