Rapid response to fluoxetine in women with premenstrual dysphoric disorder.
Rapid response to fluoxetine in women with premenstrual dysphoric disorder.
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DOI：
10.1002/da.21959
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发表时间：
2012-06
影响因子：
7.4
通讯作者：
Schmidt, Peter J.
中科院分区：
文献类型：
--
作者：
Steinberg, Emma M.;Cardoso, Graca M. P.;Martinez, Pedro E.;Rubinow, David R.;Schmidt, Peter J.
关键词：
选择性5 -羟色胺再摄取抑制剂（SRIs）缓解经前焦虑症（PMDD）妇女数日内的易怒；然而，经前抑郁症对其他情感症状的影响仍有待证实。我们对患有经前不悦症的女性进行了每小时评分，以测试SRIs治疗效果的特异性，并确定这些效果的动力学是否与伴随月经的症状抵消的动力学不同。12名患有经前抑郁症的妇女在月经周期的黄体期服用氟西汀（每天20毫克）。另外12名患有经前不悦症的女性没有接受任何治疗。结果测量包括未经治疗的妇女在SRIs开始前后或月经开始时每小时完成一次的视觉模拟量表和每天完成一次的经前紧张综合征（PMTS）量表。数据采用方差分析（ANOVA-R）。每小时VAS评分显著改善后，SRI在易怒，悲伤，焦虑和情绪波动。与症状前处理基线相比，在SRI开始后第2天PMTS评分显著提高（p < 0.01）。在SRI和月经开始后，症状改善的时间过程相同。这些数据表明，对SRI的快速反应并不局限于烦躁。经前抑郁发作后和经前抑郁发作后，经前抑郁缓解的相似动力学表明，这是一种表型，反映了快速改变情感状态的相对能力，以及一种可能的治疗机制，SRIs利用这种内源性改变状态的能力，通常在经前抑郁女性的月经发作前后表达。
Selective serotonin reuptake inhibitors (SRIs) relieve irritability within days in women with premenstrual dysphoric disorder (PMDD); however, the effects on other affective symptoms in PMDD remain to be demonstrated. We performed hourly ratings in women with PMDD to test the specificity of the therapeutic effects of SRIs and to determine whether the kinetics of these effects differ from those of the symptom offset accompanying menses. Twelve women with PMDD received fluoxetine (20 mg daily) during the luteal phase of the menstrual cycle. Twelve other women with PMDD received no treatment. Outcome measures included a visual analogue scale completed hourly before and after either the start of SRIs or at menses-onset in the untreated women and the premenstrual tension syndrome (PMTS) scale completed daily. Data were analyzed by ANOVA-R. Hourly VAS scores significantly improved after SRI in irritability as well as sadness, anxiety, and mood swings. Compared with the symptomatic pretreatment baseline, PMTS scores significantly improved on the second day after the start of SRI (p < .01). An identical time course of symptom improvement occurred after both SRI and menses-onset. These data document that the rapid response to SRI was not limited to irritability. The similar kinetics in the remission of PMDD after SRIs and after menses-onset suggest both a phenotype reflecting the relative capacity to rapidly change affective state, and a possible therapeutic mechanism by which SRIs recruit this endogenous capacity to change state, normally expressed around menses-onset in women with PMDD.
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影响因子：
7.6
作者：
Lee, Jong-Ju;Hahm, Eu-Teum;Cho, Young-Wuk
通讯作者：
Cho, Young-Wuk
影响因子：
158.5
作者：
STEINER, M;STEINBERG, S;STREINER, D
通讯作者：
STREINER, D
DOI：
10.1001/archfami.8.4.328
发表时间：
1999-07-01
期刊：
ARCHIVES OF FAMILY MEDICINE
影响因子：
--
作者：
Jermain, DM;Preece, CK;Sulak, PJ
通讯作者：
Sulak, PJ
影响因子：
3.2
作者：
Miner, C;Brown, E;Wohlreich, M
通讯作者：
Wohlreich, M
影响因子：
4
作者：
Robichaud, M;Debonnel, G
通讯作者：
Debonnel, G