Talaverrucin A, Heterodimeric Oxaphenalenone from Antarctica Sponge-Derived Fungus Talaromyces sp. HDN151403, Inhibits Wnt/ β-Catenin Signaling Pathway
Talaverrucin A, Heterodimeric Oxaphenalenone from Antarctica Sponge-Derived Fungus Talaromyces sp. HDN151403, Inhibits Wnt/ β-Catenin Signaling Pathway
复制标题
Talaverrucin A，来自南极洲海绵衍生真菌 Talaromyces sp. 的异二聚体 Oxaphenalenone。
DOI：
10.1021/acs.orglett.2c01394
复制
发表时间：
2022-06-10
期刊：
影响因子：
5.2
通讯作者：
Li, Dehai
中科院分区：
文献类型：
--
作者：
Sun, Chunxiao;Liu, Qianwen;Li, Dehai
The Wnt/fi-catenin signaling pathway is an evolutionarily conserved signaling cascade involved in a broad range of biological roles. Dysregulation of the Wnt/fi-catenin pathway is implicated in congenital malformations and various kinds of cancers. We discovered a novel Wnt/ficatenin inhibitor, talaverrucin A (1), featuring an unprecedented 6/6/6/5/ 5/5/6 fused ring system, from an Antarctica sponge-derived fungus Talaromyces sp. HDN151403. Talaverrucin A exhibits inhibitory activity on the Wnt/fi-catenin pathway in both zebrafish embryos in vivo and cultured mammalian cells in vitro, providing a naturally inspired small molecule therapeutic lead to target the Wnt/fi-catenin pathway.
