Educational level as a modulator of cognitive performance and neuropsychyatric features in Parkinson disease
Educational level as a modulator of cognitive performance and neuropsychyatric features in Parkinson disease
复制标题
DOI：
10.1097/wnn.0b013e3180335f8e
复制
发表时间：
2007-03-01
影响因子：
1.4
通讯作者：
Hassin-Baer, Sharon
中科院分区：
文献类型：
--
作者：
Cohen, Oren S.;Vakil, Eli;Hassin-Baer, Sharon
目的：检验帕金森病（PD）患者的教育水平（EL）、认知表现和神经精神特征之间可能存在的关联。背景：有报道称老年痴呆症阿尔茨海默型患者的EL与认知功能障碍呈负相关，但教育是否对PD患者的认知功能有类似的影响尚不清楚。方法：72例PD患者（45名男性，平均年龄68.7±11.6岁）接受了详细的神经系统检查、一系列神经心理测试和精神病、睡眠障碍和抑郁评估问卷。根据受教育年限将患者分为低EL组（0 ~ 8 y）、15例、中等EL组（9 ~ 12 y） 28例、高EL组（>= 13 y） 29例。结果：EL水平高的患者认知功能较好，其EL水平与以额叶功能障碍敏感测试为主的神经心理测试得分呈正相关。受教育程度低与出现幻觉的风险增加以及抑郁、妄想和睡眠障碍的趋势有关。结论：教育程度高与认知功能障碍风险低之间的关系提示教育可能调节PD患者的认知表现。
Objectives: To test a possible association between the educational level (EL), cognitive performance, and neuropsychiatric features in Parkinson disease (PD).Background: An inverse association has been reported between EL and cognitive dysfunction in patients with senile dementia of Alzheimer type but it is yet unsettled whether education has a similar effect on cognition in PD.Methods: Seventy-two PD patients (45 males, mean age 68.7 +/- 11.6 y) underwent a detailed neurologic examination, a battery of neuropsychologic tests, and questionnaires for the evaluation of psychosis, sleep disturbances, and depression. According to the number of educational years, patients were divided into 3 groups: low EL (0 to 8 y), (15 patients), intermediate EL (9 to 12 y) (28 patients), and high EL (>= 13 y) (29 patients).Results: Patients with a higher EL had a better cognitive function and an association was found between the patients' EL and their scores in various neuropsychologic tests mainly those sensitive to frontal lobe dysfunction. Low education was associated With an increased risk for hallucinations and a trend for more depression, delusions, and sleep disturbances.Conclusions: The association between high educational attainment and the lower risk of cognitive dysfunction suggest that education might modulate cognitive performance in PD.