Anger proneness predicts coronary heart disease risk: prospective analysis from the atherosclerosis risk in communities (ARIC) study.
Anger proneness predicts coronary heart disease risk: prospective analysis from the atherosclerosis risk in communities (ARIC) study.
复制标题
愤怒倾向预测冠心病风险：社区动脉粥样硬化风险 (ARIC) 研究的前瞻性分析。
DOI：
10.1161/01.cir.101.17.2034
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发表时间：
2000
期刊：
影响因子：
37.8
通讯作者：
Tyroler,HA
中科院分区：
文献类型：
--
作者：
Williams,JE;Paton,CC;Siegler,IC;Eigenbrodt,ML;Nieto,FJ;Tyroler,HA
背景——越来越多的研究关注愤怒对冠心病 (CHD) 的负面影响。方法和结果——本研究前瞻性地研究了特质愤怒与合并 CHD（急性心肌梗塞 [MI]/致命性 CHD、无症状 MI 或心脏血运重建手术）和“硬”事件（急性 MI/致命性 CHD）风险之间的关联。参与者是参加社区动脉粥样硬化风险研究的 12,986 名黑人和白人男性和女性。在整个队列中，与低愤怒人群相比，具有高特质愤怒的个体在这两个事件类别中患冠心病的风险更高。合并 CHD 的多变量调整风险比 (HR) (95% CI) 为 1.54 (95% CI 1.10 至 2.16)，“硬”事件为 1.75 (95% CI 1.17 至 2.64)。通过高血压状态观察到效果的异质性。在血压正常的个体中，合并冠心病和“困难”事件的风险随着特质愤怒水平的增加而单调增加。高度愤怒与低度愤怒的 CHD 多变量调整 HR 为 2.20（95% CI 1.36 至 3.55），中度愤怒与低度愤怒为 1.32（95% CI 0.94 至 1.84）。对于“困难”事件，多变量调整后的 HR 分别为 2.69（95% CI 1.48 至 4.90）和 1.35（95% CI 0.87 至 2.10）。在高血压患者中，没有观察到特质愤怒与冠心病风险之间存在统计学上的显着关联。结论——愤怒倾向使血压正常的中年男性和女性面临冠心病发病和死亡的显着风险，与既定的生物风险因素无关。
Background—Increased research attention is being paid to the negative impact of anger on coronary heart disease (CHD).Methods and Results—This study examined prospectively the association between trait anger and the risk of combined CHD (acute myocardial infarction [MI]/fatal CHD, silent MI, or cardiac revascularization procedures) and of “hard” events (acute MI/fatal CHD). Participants were 12 986 black and white men and women enrolled in the Atherosclerosis Risk In Communities study. In the entire cohort, individuals with high trait anger, compared with their low anger counterparts, were at increased risk of CHD in both event categories. The multivariate-adjusted hazard ratio (HR) (95% CI) was 1.54 (95% CI 1.10 to 2.16) for combined CHD and 1.75 (95% CI 1.17 to 2.64) for “hard” events. Heterogeneity of effect was observed by hypertensive status. Among normotensive individuals, the risk of combined CHD and of “hard” events increased monotonically with increasing levels of trait anger. The multivariate-adjusted HR of CHD for high versus low anger was 2.20 (95% CI 1.36 to 3.55) and for moderate versus low anger was 1.32 (95% CI 0.94 to 1.84). For “hard” events, the multivariate-adjusted HRs were 2.69 (95% CI 1.48 to 4.90) and 1.35 (95% CI 0.87 to 2.10), respectively. No statistically significant association between trait anger and incident CHD risk was observed among hypertensive individuals.Conclusions—Proneness to anger places normotensive middle-aged men and women at significant risk for CHD morbidity and death independent of the established biological risk factors.