High lethality of F1 (Dh/+) male mice from the cross between DDD female and DH (Dh/+) male.

High lethality of F1 (Dh/+) male mice from the cross between DDD female and DH (Dh/+) male.
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DDD 雌性和 DH (Dh/ ) 雄性杂交产生的 F1 (Dh/ ) 雄性小鼠具有高致死率。

DOI:
10.1538/expanim.45.99
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发表时间:
1996
影响因子:
2.4
通讯作者:
K. Fukuta
K. Fukuta
中科院分区:
医学4区
文献类型:
--
作者:
J. Suto;T. Wakayama;K. Imamura;S. Goto;K. Fukuta

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本研究表明,F1 (Dh/+) 雄性小鼠、DDD 雌性小鼠和近交 DH (Dh/+) 雄性小鼠的后代具有高致死率。在新生幼崽中,F1 (Dh/+) 雄性小鼠的数量与其他基因型小鼠(+/+ 雄性、Dh/+ 雌性和 +/+ 雌性)的数量相当,但许多 F1 (Dh/+) 雄性在断奶前死亡。另一方面,在 DH (Dh/+) 雌性和 DDD 雄性杂交的 F1 小鼠中,Dh 基因型幼仔的数量没有偏差。这些结果表明,雄性 Dh 基因与 DDD 雌性遗传特征之间的相互作用存在缺陷。
The present study demonstrates the incidence of high lethality of F1 (Dh/+) male mice, the offspring of DDD females and inbred DH (Dh/+) males. Among the newborn pups, the numbers of F1 (Dh/+) males are comparable to those of mice having other genotypes (+/+ male, Dh/+ female and +/+ female), but many F1 (Dh/+) males died before weaning. On the other hand, among the F1 mice from the cross between DH (Dh/+) females and DDD males, there are no biased numbers of Dh genotype pups. These results suggest the existence of defects in the interaction between the male derived Dh gene and the genetic traits of the DDD female.
Goto,N.:实验动物。
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