REARRANGEMENT OF THE VIMENTIN CYTOSKELETON DURING ADIPOSE CONVERSION - FORMATION OF AN INTERMEDIATE FILAMENT CAGE AROUND LIPID GLOBULES
REARRANGEMENT OF THE VIMENTIN CYTOSKELETON DURING ADIPOSE CONVERSION - FORMATION OF AN INTERMEDIATE FILAMENT CAGE AROUND LIPID GLOBULES
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DOI：
10.1016/0092-8674(87)90763-x
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发表时间：
1987-04-10
期刊：
影响因子：
64.5
通讯作者：
GRUND, C
中科院分区：
文献类型：
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作者：
FRANKE, WW;HERGT, M;GRUND, C
在小鼠3T3-L1细胞的脂肪转化过程中，波形蛋白中间丝(IFs)的排列从延伸的纤维状变为与形成的脂球紧密相关的复杂的笼状结构。围绕着脂球的完全发育的笼状复合体由一组规则分布的波形蛋白IF组成，这些IF又被一个特殊的内质网池紧密包裹。在培养和组织中的其他脂肪细胞中也可以看到同样的IF-CAGE。脂肪转化过程中脂肪小球与Vimentin IF的联系的特异性被讨论为支持脂肪形成的一种特殊的区划形式，并被作为与细胞分化过程有关的可能的IF功能的一个例子。
During adipose conversion of murine 3T3-L1 cells, the arrangement of vimentin intermediate filaments (IFs) changes from an extended fibrillar state to a complex cage formation tightly associated with the forming lipid globules. The fully developed cage complex surrounding the lipid globule consists of a monolayer of groups of regularly spaced vimentin IFs that in turn is closely ensheathed by a special endoplasmic reticulum cisterna. The same IF cage is also seen in other adipocytes in culture and in tissues. The specificity of the association of lipid globules with vimentin IFs during adipose conversion is discussed as a special form of compartmentalization supporting adipogenesis and is taken as an example of a possible IF function in relation to a cell differentiation process.