The generation mechanism of spike-and-slow wave discharges appearing on thalamic relay nuclei.
The generation mechanism of spike-and-slow wave discharges appearing on thalamic relay nuclei.
复制标题
丘脑中继核尖慢波放电的产生机制
DOI：
10.1038/s41598-018-23280-y
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发表时间：
2018-03-21
影响因子：
4.6
通讯作者：
Chen L
中科院分区：
文献类型：
--
作者：
Hu B;Guo Y;Shi F;Zou X;Dong J;Pan L;Yu M;Zhou C;Cheng Z;Tang W;Sun H;Chen L
在本文中，我们使用经典皮质丘脑网络（CT）修改的模型来探讨丘脑特定中继核（SRN）出现失神发作的机制。通过调整模型中的几个关键连接强度，发现SRN上出现了典型的癫痫状态。鉴于之前的实验和理论工作主要关注皮质兴奋性锥体神经元（EPN）上出现的癫痫发作现象，这是考虑在丘脑上观察到的癫痫发作的新模型。尤其是其发病机制与以往的理论研究不同。受之前一些临床和实验研究的启发，我们对网络中的EPN和SRN施加外部刺激电压，观察到通过适当调整刺激强度可以很好地抑制癫痫发作。我们进一步探讨了信号传输延迟对癫痫发作的影响，发现只有当延迟足够大时才会出现多尖峰现象。实验数据也证实了我们的模型。由于大脑中存在复杂的网络，各个组织之间相互作用密切，因此本文获得的结果不仅为调控机制提供了生物学见解，而且为未来癫痫的预防和治疗提供了参考。
In this paper, we use a model modified from classic corticothalamic network(CT) to explore the mechanism of absence seizures appearing on specific relay nuclei (SRN) of the thalamus. It is found that typical seizure states appear on SRN through tuning several critical connection strengths in the model. In view of previous experimental and theoretical works which were mainly on epilepsy seizure phenomena appearing on excitatory pyramidal neurons (EPN) of the cortex, this is a novel model to consider the seizure observed on thalamus. In particular, the onset mechanism is different from previous theoretical studies. Inspired by some previous clinical and experimental studies, we employ the external stimuli voltage on EPN and SRN in the network, and observe that the seizure can be well inhibited by tuning the stimulus intensity appropriately. We further explore the effect of the signal transmission delays on seizures, and found that the polyspike phenomenon appears only when the delay is sufficiently large. The experimental data also confirmed our model. Since there is a complex network in the brain and all organizations are interacting closely with each other, the results obtained in this paper provide not only biological insights into the regulatory mechanisms but also a reference for the prevention and treatment of epilepsy in future.
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影响因子：
82.9
作者：
Cope, David W.;Di Giovanni, Giuseppe;Fyson, Sarah J.;Orban, Gergely;Errington, Adam C.;Lorincz, Magor L.;Gould, Timothy M.;Carter, David A.;Crunelli, Vincenzo
通讯作者：
Crunelli, Vincenzo
基底神经节对失神发作的双向控制：计算证据
影响因子：
4.3
作者：
Chen M;Guo D;Wang T;Jing W;Xia Y;Xu P;Luo C;Valdes-Sosa PA;Yao D
通讯作者：
Yao D
影响因子：
3.7
作者：
Breakspear, M.;Roberts, J. A.;Robinson, P. A.
通讯作者：
Robinson, P. A.
影响因子：
2.5
作者：
Bessaih, Thomas;Bourgeais, Laurence;Leresche, Nathalie
通讯作者：
Leresche, Nathalie
影响因子：
5.6
作者：
Fisher, Robert;Salanova, Vicenta;Graves, Nina
通讯作者：
Graves, Nina