Shared molecular strategies of the malaria parasite P. falciparum and the human virus HIV-1.
Shared molecular strategies of the malaria parasite P. falciparum and the human virus HIV-1.
复制标题
疟原虫恶性疟原虫和人类病毒 HIV-1 的共同分子策略。
DOI：
10.1074/mcp.m111.009035
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发表时间：
2011
期刊：
影响因子：
--
通讯作者：
Ferdig,MichaelT
中科院分区：
文献类型：
--
作者：
Wuchty,Stefan;Siwo,GeoffreyH;Ferdig,MichaelT
We augmented existing computationally predicted and experimentally determined interactions with evolutionarily conserved interactions between proteins of the malaria parasite,P. falciparum, and the human host. In a validation step, we found that conserved interacting host-parasite protein pairs were specifically expressed in host tissues where both the parasite and host proteins are known to be active. We compared host-parasite interactions with experimentally verified interactions between human host proteins and a very different pathogen, HIV-1. Both pathogens were found to use their protein repertoire in a combinatorial manner, providing a broad connection to host cellular processes. Specifically, the two biologically distinct pathogens predominately target central proteins to take control of a human host cell, effectively reaching into diversified cellular host cellular functions. Interacting signaling pathways and a small set of regulatory and signaling proteins were prime targets of both pathogens, suggesting remarkably similar patterns of host-pathogen interactions despite the vast biological differences of both pathogens. Such an identification of shared molecular strategies by the virus HIV-1 and the eukaryotic intracellular pathogenP. falciparummay allow us to illuminate new avenues of disease intervention.
