Metabolic Evaluation in Stone Disease Metabolic Differences Between the Pediatric and Adult Patients With Stone Disease
Metabolic Evaluation in Stone Disease Metabolic Differences Between the Pediatric and Adult Patients With Stone Disease
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DOI：
10.1016/j.urology.2010.01.036
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发表时间：
2010-07-01
期刊：
影响因子：
2.1
通讯作者：
Altug, Ugur
中科院分区：
文献类型：
--
作者：
Karabacak, Osman Raif;Ipek, Bulent;Altug, Ugur
目的确定代谢危险因素在儿童和成人结石病和任何儿童和成人患者的代谢危险因素之间的差异，结石disease.METHODS在1999年和2007年，285例成人复发性结石病和71例儿童原发性或复发性泌尿系结石病在我们的诊所进行了代谢评估。评估包括血液化学研究和24小时尿液收集在儿童和成人group. Results的平均年龄为9.35岁（范围：1-14）和42.1岁（范围：14-71）在成人患者。90.53%（n = 258）的成人和88.73%（n = 63）的儿童患者存在代谢危险因素。虽然高钙尿（50.5%，n = 144）是成人组中最常见的代谢危险因素，但低柠檬酸尿是儿科组中最常见的代谢危险因素（57.74%，n = 41）。结论虽然低柠檬酸尿是儿童尿石症最常见的危险因素，高钙尿是成人尿石症最常见的危险因素，所有有结石形成的患者都应该进行有限的代谢评估，因为这些患者也可能有代谢异常。泌尿学76：238-241，2010年。(C)2010年爱思唯尔公司
OBJECTIVE To determine the metabolic risk factors in children and adults with stone disease and any differences between the metabolic risk factors of children and adult patients with stone disease.METHODS Between 1999 and 2007, 285 adults with recurrent stone disease and 71 children with primary or recurrent urinary stone disease underwent metabolic evaluation in our clinic. The evaluation included blood chemistry studies and 24-hour urine collection in the pediatric and adult groups.RESULTS The mean age of the children was 9.35 years (range: 1-14) and 42.1 years (range: 14-71) in the adult patients. Metabolic risk factors were demonstrated in 90.53% (n = 258) of the adult and 88.73% (n = 63) of the pediatric patients. Although hypercalciuria (50.5%, n = 144) was the most common metabolic risk factor in the adult group, hypocitraturia was the most common metabolic risk factor in the pediatric group (57.74%, n = 41). Furthermore, in the adult group, 136 patients had more than 1 risk factor, and in the pediatric group, 24 patients had more than 1 risk factor.CONCLUSION Although hypocitraturia is the most common risk factor in pediatric urolithiasis patients and hypercalciuria is the most common risk factor in adult patients, all patients with stone formation should be given a limited metabolic evaluation because such patients may also have a metabolic abnormality. UROLOGY 76: 238-241, 2010. (C) 2010 Elsevier Inc.