The biology of gonadotroph regulation.
The biology of gonadotroph regulation.
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DOI：
10.1097/med.0b013e32832d88fb
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发表时间：
2009-08
期刊：
影响因子：
--
通讯作者：
Kaiser UB
中科院分区：
文献类型：
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作者：
Ciccone NA;Kaiser UB
讨论垂体促性腺激素发育和促性腺激素基因调控的最新进展，重点是不同的促黄体生成激素（LH）和促卵泡激素（FSH）分泌和亚基合成，以及这可能对女性生殖健康的影响。在成熟的促性腺激素细胞中，有一个新兴的概念，即促性腺激素β亚基基因的差异合成，对周期性生殖功能至关重要，与重要的调节蛋白和转录因子的激活和/或稳定性的修饰有关。最近的研究表明，影响组蛋白修饰的细胞事件在促性腺激素细胞发育和促性腺激素亚单位基因表达的个体发生中起着重要作用。这种动态事件是在下丘脑神经肽促性腺激素释放激素（GnRH）的协调下，可能通过GnRH激活促性腺激素细胞内几个不同的信号级联的能力。对促性腺激素生理学关键的细胞事件的更深入了解将有助于我们理解下丘脑性闭经和多囊卵巢综合征（PCOS）等疾病中促性腺激素分泌异常，并为设计新的治疗方法提供背景。
To discuss recent progress in our understanding of pituitary gonadotroph development and gonadotropin gene regulation, with an emphasis on differential luteinizing hormone (LH) and follicle-stimulating hormone (FSH) secretion and subunit synthesis, and the implications this may have on female reproductive health. In the mature gonadotroph, there is an emerging concept that differential synthesis of gonadotropin β-subunit genes, essential for cyclic reproductive function, is associated with modification of activation and/or stability of important regulatory proteins and transcription factors. Recent studies suggest that cellular events, which affect histone modification, play an essential role in both gonadotroph development and the ontogeny of gonadotropin subunit gene expression. Such dynamic events are under the orchestration of the hypothalamic neuropeptide gonadotropin-releasing hormone (GnRH), potentially through the ability of GnRH to activate several distinct signaling cascades within the gonadotroph. Greater insight into the cellular events that are key to gonadotroph physiology will contribute to our understanding of abnormal gonadotropin secretion in disorders such as hypothalamic amenorrhea and polycystic ovarian syndrome (PCOS), and provide a context for the design of novel therapeutic approaches.