The brain-specific microRNA miR-128b regulates the formation of fear-extinction memory
The brain-specific microRNA miR-128b regulates the formation of fear-extinction memory
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DOI：
10.1038/nn.2891
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发表时间：
2011-09-01
影响因子：
25
通讯作者：
Bredy, Timothy W.
中科院分区：
文献类型：
--
作者：
Lin, Quan;Wei, Wei;Bredy, Timothy W.
MicroRNA 是介导转录后基因沉默的小型非编码 RNA。 C57/Bl6J 小鼠的恐惧消退学习导致大脑特异性 microRNA miR-128b 的表达增加，从而破坏了几个可塑性相关靶基因的稳定性并调节了恐惧消退记忆的形成。因此，miR-128b 活性的增加可能促进从原始恐惧记忆的检索到新的恐惧消除记忆的形成的转变。
MicroRNAs are small non-coding RNAs that mediate post-transcriptional gene silencing. Fear-extinction learning in C57/Bl6J mice led to increased expression of the brain-specific microRNA miR-128b, which disrupted stability of several plasticity-related target genes and regulated formation of fear-extinction memory. Increased miR-128b activity may therefore facilitate the transition from retrieval of the original fear memory toward the formation of a new fear-extinction memory.