Full length and delta lactoferrin display differential cell localization dynamics, but do not act as tumor markers or significantly affect the expression of other genes.
Full length and delta lactoferrin display differential cell localization dynamics, but do not act as tumor markers or significantly affect the expression of other genes.
复制标题
DOI：
10.2174/1573406053402532
复制
发表时间：
2005-01-01
期刊：
影响因子：
--
通讯作者：
Tsuda, Hiroyuki
中科院分区：
文献类型：
--
作者：
Goldberg, Gary S;Kunimoto, Takehiko;Tsuda, Hiroyuki
乳铁蛋白是一种与转铁蛋白相关的分泌型蛋白质。乳铁蛋白通过杀灭细菌，清除游离铁，并与病毒入侵所需的受体结合，间接保护宿主细胞免受外来侮辱。然而，乳铁蛋白也被认为是作为一种转录因子和肿瘤抑制基因直接作用于细胞。除了全长乳铁蛋白，还可以通过选择性剪接产生一种截短形式，称为增量乳铁蛋白。我们在这里表明，转化的和未转化的细胞同样能够表达全长和增量乳铁蛋白。此外，这两种形式的乳铁蛋白都未能实质上调节其他基因的表达。因此，乳铁蛋白似乎不能直接控制基因表达或抑制肿瘤细胞生长。
Lactoferrin is a secreted protein related to transferrin. Lactoferrin indirectly protects host cells against foreign insults by killing bacteria, scavenging free iron, and binding to receptors required for viral invasion. However, lactoferrin is also proposed to act directly on cells as a transcription factor and tumor suppressor gene. In addition to full length lactoferrin, a truncated form, called delta lactoferrin, can also be produced by alternative splicing. We show here that transformed and nontransformed cells are equally able to express both full length and delta lactoferrin. Moreover, both forms of lactoferrin failed to substantially modulate the expression of other genes. Thus, lactoferrin does not seem to directly control gene expression or inhibit tumor cell growth.