Cardiac Hypertrophy: An Introduction to Molecular and Cellular Basis.
Cardiac Hypertrophy: An Introduction to Molecular and Cellular Basis.
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DOI：
10.12659/msmbr.900437
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发表时间：
2016-07-23
影响因子：
2.8
通讯作者：
Weymann A
中科院分区：
文献类型：
--
作者：
Samak M;Fatullayev J;Sabashnikov A;Zeriouh M;Schmack B;Farag M;Popov AF;Dohmen PM;Choi YH;Wahlers T;Weymann A
心室肥大是血流动力学应激性疾病（如高血压和瓣膜疾病）的一种不祥的升级。肥大的病理生理学是复杂和多因素的，因为它涉及几个细胞和分子系统。了解心脏肥大的分子背景对于保护心肌免受病理性重塑或减缓注定的心力衰竭进展至关重要。在这篇综述中，我们强调了最重要的心脏肥大性生长的分子方面，根据目前已发表的研究数据。
Ventricular hypertrophy is an ominous escalation of hemodynamically stressful conditions such as hypertension and valve disease. The pathophysiology of hypertrophy is complex and multifactorial, as it touches on several cellular and molecular systems. Understanding the molecular background of cardiac hypertrophy is essential in order to protect the myocardium from pathological remodeling, or slow down the destined progression to heart failure. In this review we highlight the most important molecular aspects of cardiac hypertrophic growth in light of the currently available published research data.