New approaches to amphibian limb regeneration.
New approaches to amphibian limb regeneration.
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DOI：
10.1016/0168-9525(94)90094-9
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发表时间：
1994-05
期刊：
影响因子：
--
通讯作者：
J. Brockes
中科院分区：
文献类型：
--
作者：
J. Brockes
有尾目两栖动物的肢体再生是通过形成芽基（间充质祖细胞的生长区）进行的。在这里，我回顾芽基的起源和它的位置的身份。培养和重新植入蝾螈芽基细胞的能力，并在培养和原位使用粒子传递系统，使他们的行为，视黄酸的芽基和肌肉分化的逆转肢体再生过程中产生了新的信息。
Limb regeneration in urodele amphibians proceeds by the formation of a blastema, a growth zone of mesenchymal progenitor cells. Here, I review the origin of the blastema and its positional identity. The ability to culture and reimplant newt blastemal cells, and to transfect them in culture and in situ using a particle delivery system, has yielded new information about the action of retinoic acid on the blastema and the reversal of muscle differentiation during limb regeneration.