Why do species vary in their rate of molecular evolution?
Why do species vary in their rate of molecular evolution?
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DOI：
10.1098/rsbl.2009.0136
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发表时间：
2009-06-23
期刊：
影响因子：
3.3
通讯作者：
Bromham, Lindell
中科院分区：
文献类型：
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作者：
Bromham, Lindell
尽管人们希望分子进化的过程将是简单的、钟状的、本质上是普遍的，但分子进化速度的差异在生物组织的所有层面上都是明显的。此外，很明显，速率变化有一个系统的组成部分：分子进化速率可以随着物种的身体大小、种群动态、生活方式和位置而一致地变化。这表明，分子进化的速度应该被认为是物种间生活史差异的一部分，在解释谱系之间的DNA序列差异时必须考虑到这一点。揭示速率变异的原因和相互关系可能允许开发新的生物驱动的分子进化模型，这些模型可能会改进生物信息学和系统发育分析。
Despite hopes that the processes of molecular evolution would be simple, clock-like and essentially universal, variation in the rate of molecular evolution is manifest at all levels of biological organization. Furthermore, it has become clear that rate variation has a systematic component: rate of molecular evolution can vary consistently with species body size, population dynamics, lifestyle and location. This suggests that the rate of molecular evolution should be considered part of life-history variation between species, which must be taken into account when interpreting DNA sequence differences between lineages. Uncovering the causes and correlates of rate variation may allow the development of new biologically motivated models of molecular evolution that may improve bioinformatic and phylogenetic analyses.