Plasma Elaidic Acid Level as Biomarker of Industrial Trans Fatty Acids and Risk of Weight Change: Report from the EPIC Study
Plasma Elaidic Acid Level as Biomarker of Industrial Trans Fatty Acids and Risk of Weight Change: Report from the EPIC Study
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DOI：
10.1371/journal.pone.0118206
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发表时间：
2015-02-12
期刊：
影响因子：
3.7
通讯作者：
Slimani, Nadia
中科院分区：
文献类型：
--
作者：
Chajes, Veronique;Biessy, Carine;Slimani, Nadia
研究背景很少有流行病学研究调查饮食中反式脂肪酸与体重增加之间的关系，而且证据仍然不一致。这项研究的主要目的是探讨工业反式脂肪酸的生物标志物和在大型研究欧洲前瞻性调查到癌症和营养（EPIC）cohol.MethodsBaseline的体重变化之间的前瞻性关联确定在一个有代表性的EPIC样本从23个参与EPIC中心。共有1，945人接受了中位数为4.9年的随访，以监测体重变化。采用多项逻辑回归模型，根据随访时间、年龄、能量、酒精、吸烟状况、体力活动和地区进行调整，研究了弹性酸水平与体重变化百分比之间的关系。（比值比（OR）= 0.69，95%置信区间（CI）= 0.55- 0.88，p = 0.002），在5年随访期间观察到体重增加风险增加的趋势（OR = 1.23，95% CI = 0.97- 1.56，p = 0.082）（p-趋势
BackgroundFew epidemiological studies have examined the association between dietary trans fatty acids and weight gain, and the evidence remains inconsistent. The main objective of the study was to investigate the prospective association between biomarker of industrial trans fatty acids and change in weight within the large study European Prospective Investigation into Cancer and Nutrition ( EPIC) cohort.MethodsBaseline plasma fatty acid concentrations were determined in a representative EPIC sample from the 23 participating EPIC centers. A total of 1,945 individuals were followed for a median of 4.9 years to monitor weight change. The association between elaidic acid level and percent change of weight was investigated using a multinomial logistic regression model, adjusted by length of follow- up, age, energy, alcohol, smoking status, physical activity, and region.ResultsIn women, doubling elaidic acid was associated with a decreased risk of weight loss ( odds ratio ( OR) = 0.69, 95% confidence interval ( CI) = 0.55- 0.88, p = 0.002) and a trend was observed with an increased risk of weight gain during the 5- year follow- up ( OR = 1.23, 95% CI = 0.97- 1.56, p = 0.082) ( p- trend