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DOI：
10.1002/(issn)1520-6777
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发表时间：
2020-01
影响因子：
2
通讯作者：
R. Dmochowski
中科院分区：
文献类型：
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作者：
R. Dmochowski
通信作者Kiyohide Fujimoto，奈良医科大学泌尿外科，840 Shijo-cho，奈良634 - 8522，Japan。电子邮件：kiyokun@naramed-u.ac.jpwww.example.com确定单一症状性夜间遗尿症（MNE）儿童的尿神经生长因子（NGF）和脑源性神经营养因子（BDNF）水平，并评估这些因素是否可用作治疗结果的生物标志物。研究方法：对38例MNE患儿（男28例，女10例）和25例无泌尿系症状患儿（男18例，女7例）的NGF和BDNF水平进行了检测和比较。患者组和对照组的平均年龄分别为9岁和10岁（P= 0.49）。患者接受了警报或去氨加压素治疗。结果如下：患者组的尿NGF/肌酐和BDNF/肌酐比值显著高于对照组（分别为P= 0.0003和P= 0.0095）。NGF和BDNF水平呈显著正相关（P= 0.0020，r= 0.40）。在缓解程度方面，19例（50%）患者显示完全缓解（CR）或部分缓解（PR），19例（50%）患者显示无缓解（NR）。NR组的尿NGF/肌酐和BDNF/肌酐比值显著高于CR组和PR组（分别为P= .0003和P= .0003）。结论：尿神经生长因子/肌酐和脑源性神经营养因子/肌酐的比例显着高于儿童MNE比健康对照组。尿神经生长因子/肌酐可以作为MNE患儿治疗效果差的预测因素。
Correspondence Kiyohide Fujimoto, Department of Urology, Nara Medical University, 840 Shijo‐cho, Nara 634‐8522, Japan. Email: kiyokun@naramed-u.ac.jp Abstract Aim: To determine the urinary levels of nerve growth factor (NGF) and brain‐ derived neurotrophic factor (BDNF) in children with monosymptomatic nocturnal enuresis (MNE) and evaluate whether these factors can be used as biomarkers for the treatment outcome. Methods: NGF and BDNF levels were measured and compared in 38 children (28 boys and 10 girls) with MNE and 25 children (18 boys and 7 girls) with no urinary symptoms were assessed. The mean ages in the patient and control groups were 9 and 10 years, respectively (P= .49). The patients were treated with either alarm or desmopressin therapy. Results: The urinary NGF/creatinine and BDNF/creatinine ratios were significantly higher in the patient group than in the control group (P= .0003 and P= .0095, respectively). NGF and BDNF levels showed a significant positive correlation (P= .0020, r= 0.40). With respect to the degree of response, 19 patients (50%) showed complete response (CR) or partial response (PR), and 19 patients (50%) showed nonresponse (NR). The urinary NGF/creatinine and BDNF/creatinine ratios were significantly higher in the NR group than in the CR and PR groups (P= .0003 and P= .0003, respectively). Conclusions: Urinary NGF/creatinine and BDNF/creatinine ratios were significantly higher in children with MNE than in healthy controls. Urinary NGF/creatinine can be predictive factors of a poor treatment outcome in children with MNE.