The International Hundred Thousand Plus Cohort Consortium: integrating large-scale cohorts to address global scientific challenges.
The International Hundred Thousand Plus Cohort Consortium: integrating large-scale cohorts to address global scientific challenges.
复制标题
DOI：
10.1016/s2589-7500(20)30242-9
复制
发表时间：
2020-11
期刊：
影响因子：
--
通讯作者：
Ginsburg G
中科院分区：
文献类型：
--
作者：
Manolio TA;Goodhand P;Ginsburg G
在全世界几个地区建立或启动了涉及数十万参与者的大型队列研究。队列研究为研究不同人群和关键人口统计学亚组、罕见基因型和暴露以及基因环境相互作用提供了巨大价值。[1]然而，每个队列都受到其规模、祖先来源和地理边界的限制，这限制了它可以研究的亚组、暴露、结果和相互作用。将大型队列的数据联系起来，提供了一个包含各种数据的庞大数字资源，以解决这些队列中没有一个能够单独回答的问题，从而提高了每个队列的价值，并利用了迄今为止在这些队列中所做的巨大投资。在美国国立卫生研究院和威康信托基金的支持下，并与全球基因组学与健康联盟（GA4GH）和全球基因组医学合作组织（G2MC）合作，共同组建了国际十万多人队列联盟（IHCC）。截至2020年5月，IHCC包括43个国家的103个队列，涉及近5000万参与者（图，附录）。迄今为止，合作努力的重点是开发一个可查询的群组登记和数据共享平台，确定和试点高度优先的科学项目，并制定一个章程和治理结构，以促进合作。
Large cohort studies involving hundreds of thousands of participants have been established or launched in several regions worldwide. Cohorts provide great value for studying diverse populations and key demographic subgroups, rare genotypes and exposures, and geneenvironment interactions. 1 Each cohort is constrained, however, by its size, ancestral origins, and geographical boundaries, which limit the subgroups, exposures, outcomes, and interactions it can examine. Linking data across large cohorts provides a vast digital resource of diverse data to address questions that none of these cohorts can answer alone, enhancing the value of each cohort and leveraging the enormous investments made in them to date.Leaders of large-scale cohorts, with support from the National Institutes of Health and the Wellcome Trust, and in collaboration with the Global Alliance for Genomics and Health (GA4GH) and the Global Genomic Medicine Collaborative (G2MC), have come together to form the International Hundred Thousand Plus Cohort Consortium (IHCC). As of May, 2020, IHCC comprises 103 cohorts in 43 countries involving nearly 50 million participants (figure, appendix). Collaborative efforts to date have focused on developing a queryable cohort registry and data sharing platform, identifying and piloting high-priority scientific projects, and developing a charter and governance structure to foster collaborations.