IMMUNOLOGICAL SPECIFICITY
IMMUNOLOGICAL SPECIFICITY
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DOI：
10.1126/science.129.3364.1643
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发表时间：
1959-01-01
期刊：
影响因子：
56.9
通讯作者：
TALMAGE, DW
中科院分区：
文献类型：
--
作者：
TALMAGE, DW
基于天然球蛋白的独特组合的免疫特异性概念是对每种可能抗原的独特球蛋白分子的经典概念的有吸引力的替代方案。迄今为止，抗体反应的许多独立方面，例如抗体多样性、交叉反应、天然抗体、淋巴组织中增加的有丝分裂、记忆反应和免疫耐受，可能与抗体产生不是独特的生物现象而是某些一般细胞过程的高度专门化的例子有关。
The concept of immunological specificity based on a unique combination of natural globulins is an attractive alternative to the classical concept of unique globulin molecules for each possible antigen. Many hitherto separate facets of the antibody response such as antibody diversity, cross-reactions, natural antibodies, increased mitoses in lymphatic tissue, the anamnestic response, and immune tolerance may be related through the general thesis that antibody production is not a unique biological phenomenon but a highly specialized example of certain general cellular processes.