Oral L-arginine improves endothelial function in healthy individuals older than 70 years
Oral L-arginine improves endothelial function in healthy individuals older than 70 years
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DOI：
10.1191/1358863x03vm474oa
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发表时间：
2003-05-01
影响因子：
3.5
通讯作者：
Frölich, JC
中科院分区：
文献类型：
--
作者：
Bode-Böger, SM;Muke, J;Frölich, JC
衰老与正常人进行性内皮功能障碍有关。在患有心血管疾病的老年人中，肱动脉的流量介导的扩张（FMD）受损，血管一氧化氮（NO）生物利用度降低。我们研究了口服L-精氨酸（NO合成的底物）是否可以改善健康老年人受损的FMD。在一项前瞻性、双盲、随机交叉试验中，12名健康老年受试者（年龄73.8 +/-2.7岁）服用L-精氨酸（口服8 g）每日两次）或安慰剂，每次14天，间隔14天的洗脱期。在反应性充血期间，通过肱动脉的高分辨率超声确定FMD。基线动脉直径为3.88 ± 0.18 mm。L-精氨酸显著改善FMD（至5.7 ± 1.2%，p
Ageing is associated with progressive endothelial dysfunction in normal humans. Flow-mediated dilation (FMD) of the brachial artery is impaired in elderly individuals with cardiovascular disease and vascular nitric oxide (NO) bioavailability is reduced. We investigated whether oral L-arginine, the substrate for NO synthesis, can improve impaired FMD in healthy very old people. In a prospective, double-blind, randomized crossover trial, 12 healthy old subjects (age 73.8+/-2.7 years) took L-arginine (8 g p.o. two times daily) or placebo for 14 days each, separated by a wash-out period of 14 days. FMD was determined by high-resolution ultrasound in the brachial artery during reactive hyperaemia. Baseline artery diameter was 3.88+/-0.18 mm. L-Arginine significantly improved FMD (to 5.7+/-1.2%, p