A method for determining the statistical significance of mutation frequencies
A method for determining the statistical significance of mutation frequencies
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确定突变频率统计显着性的方法
DOI：
10.1002/bimj.4710220109
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发表时间：
1980
期刊：
影响因子：
--
通讯作者：
H. Traut
中科院分区：
文献类型：
--
作者：
H. Traut
设计了一种方法，用于确定用潜在诱变剂治疗后观察到的突变频率与其对照频率之间差异的统计显著性。然而，只有当各自的控制值基于大量可靠的材料（“稳定的”对照）时，才能使用该程序，这一要求似乎至少在用于诱变筛选的部分系统中得到满足。与2检验和KASTENBAUM-BOWMAN检验相比，所提出的程序有一些优点，最重要的一点是，当这两种检验不能（因为2检验的期望频率<5，KASTENBAUM-BOWMAN检验的N和p值表有限）时，可以使用它。在解释了这个过程之后，通过两个例子（果蝇的隐性性连锁致命突变和人类淋巴细胞的双中心染色体）给出了如何实施的说明。
A method is devised for determining the statistical significance of the difference between a mutation frequency observed after treatment with a potential mutagen and its control frequency. This procedure, however, can be used only when the respective control value is based on large and reliable material (“stable” controls), a requirement that seems to be met in at least part of the systems used for mutagenesis screening. The procedure proposed has some advantages when compared with the 2 and the KASTENBAUM-BOWMAN test, the most important one being that it can be employed when these two tests cannot (because of expected frequencies <5 in the 2 test and limited tabulations of the N and p values in the KASTENBAUM-BOWMAN test). After explaining the procedure, an instruction how to carry it out is presented and illustrated by two examples (recessive sex-linked lethal mutations in Drosophila melanogaster and dicentric chromosomes in human lymphocytes).