Association between High Levels of Circulating Chemerin and Colorectal Adenoma in Men
Association between High Levels of Circulating Chemerin and Colorectal Adenoma in Men
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DOI：
10.1159/000501477
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发表时间：
2019-07
期刊：
影响因子：
3.2
通讯作者：
M. Yagi;Y. Sasaki;Y. Abe;Takao Yaoita;Kazuhiro Sakuta;Naoko Mizumoto;Masakuni Shoji;Y. Onozato;Takashi Kon;S. Nishise;Y. Ueno
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文献类型：
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作者：
M. Yagi;Y. Sasaki;Y. Abe;Takao Yaoita;Kazuhiro Sakuta;Naoko Mizumoto;Masakuni Shoji;Y. Onozato;Takashi Kon;S. Nishise;Y. Ueno
背景：肥胖和代谢综合征被认为是结直肠腺瘤（CRA）和结直肠癌（CRC）的危险因素。Chemerin是一种新的脂肪细胞因子，与胃癌、食管癌、肝细胞癌和结直肠癌的发生有关。然而，chemerin水平和CRA之间的关系仍不清楚。目的：探讨血清chemerin水平与CRA发生的关系。研究方法：我们对80例CRA男性患者和80例年龄匹配的无CRA男性对照者进行了一项基于结肠镜检查的横断面病例对照研究。采用双抗体夹心酶联免疫吸附法测定血清chemerin浓度，Logistic回归分析计算CRA的OR值。结果如下：CRA组的平均血清chemerin水平显著高于对照组（7.9 ± 0.41对5.16 ± 0.34 ng/mL，p < 0.001）。血清chemerin水平与CRA的发生呈正相关（r = 0.34）。多因素Logistic回归分析显示，高chemerin水平与CRA的发生独立相关（OR 2.82，95%CI 1.39-5.72）。结论：我们的研究结果表明，血清chemerin水平升高与男性CRA的存在呈正相关。Chemerin可能在CRA的发生发展中起重要作用。
Background: Obesity and metabolic syndrome are considered the risk factors of colorectal adenoma (CRA) and colorectal cancer (CRC). Chemerin is a novel adipocytokine associated with the development of gastric cancer, esophageal cancer, hepatocellular carcinoma, and CRC. However, the relationship between chemerin levels and CRA remains unclear. Objective: This study is aimed at investigating the association between serum chemerin levels and the development of CRA. Methods: We conducted a total colonoscopy-based cross-sectional case-control study of 80 male patients with CRA and 80 male age-matched control individuals without CRA, according to their endoscopic findings. Serum chemerin concentrations were measured using a sandwich enzyme-linked immunosorbent assay kit, and the OR of CRA was calculated via logistic regression analysis. Results: The mean serum chemerin level of the CRA group was significantly higher than that of the control group (7.9 ± 0.41 vs. 5.16 ± 0.34 ng/mL, p < 0.001). Serum chemerin level was positively correlated to the development of CRA (r = 0.34). Multivariate logistic regression analysis revealed that a high chemerin level was independently associated with the development of CRA (OR 2.82, 95% CI 1.39–5.72). Conclusions: Our findings indicated that increased serum chemerin levels are positively associated with the presence of CRA in men. Chemerin may play an important role in the development of CRA.