Relationship between tendon stiffness and failure: a metaanalysis
Relationship between tendon stiffness and failure: a metaanalysis
复制标题
DOI：
10.1152/japplphysiol.01449.2012
复制
发表时间：
2013-07-01
影响因子：
3.3
通讯作者：
Vanderby, Ray, Jr.
中科院分区：
文献类型：
--
作者：
LaCroix, Andrew S.;Duenwald-Kuehl, Sarah E.;Vanderby, Ray, Jr.
肌腱是一种高度专业化的分层组织，旨在将力从肌肉传递到骨骼;复杂的粘弹性和各向异性行为已被广泛表征为肌腱的特定子集。报告的力学数据一致显示，在初始趾部区域之后具有线性斜率的应变行为。许多研究报告的线性，弹性模量，或杨氏模量（以下称为弹性模量）和极限应力为他们的肌腱标本。个别而言，这些研究无法提供更广泛的肌腱力学行为的研究间理解。在这里，我们提出了一个荟萃分析汇总的机械数据，从一个代表性的样本肌腱从不同的物种。这些数据包括健康的肌腱和那些因损伤和愈合、基因修饰、同种异体移植物制备、机械环境和年龄而改变的肌腱。我们选取了50篇研究进行分析。尽管物种之间和物种内的力学性能范围很广，但弹性模量和极限应力高度相关（R-2 = 0.785），表明肌腱失效高度依赖于应变。此外，观察到这种关系是可预测的控制范围内的弹性模量，这将是典型的任何个别物种。通过这项荟萃分析获得的知识，非侵入性工具可以测量体内弹性模量，并合理地预测患病或受伤肌腱的极限应力（或结构妥协）。
Tendon is a highly specialized, hierarchical tissue designed to transfer forces from muscle to bone; complex viscoelastic and anisotropic behaviors have been extensively characterized for specific subsets of tendons. Reported mechanical data consistently show a pseudoelastic, stress-vs.-strain behavior with a linear slope after an initial toe region. Many studies report a linear, elastic modulus, or Young's modulus (hereafter called elastic modulus) and ultimate stress for their tendon specimens. Individually, these studies are unable to provide a broader, interstudy understanding of tendon mechanical behavior. Herein we present a metaanalysis of pooled mechanical data from a representative sample of tendons from different species. These data include healthy tendons and those altered by injury and healing, genetic modification, allograft preparation, mechanical environment, and age. Fifty studies were selected and analyzed. Despite a wide range of mechanical properties between and within species, elastic modulus and ultimate stress are highly correlated (R-2 = 0.785), suggesting that tendon failure is highly strain-dependent. Furthermore, this relationship was observed to be predictable over controlled ranges of elastic moduli, as would be typical of any individual species. With the knowledge gained through this metaanalysis, noninvasive tools could measure elastic modulus in vivo and reasonably predict ultimate stress (or structural compromise) for diseased or injured tendon.