A placebo-controlled study of sertraline's effect on cortisol response to the dexamethasone/corticotropin-releasing hormone test in healthy adults.
A placebo-controlled study of sertraline's effect on cortisol response to the dexamethasone/corticotropin-releasing hormone test in healthy adults.
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DOI：
10.1007/s00213-011-2336-y
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发表时间：
2011-11
影响因子：
3.4
通讯作者：
Price, Lawrence H.
中科院分区：
文献类型：
--
作者：
Carpenter, Linda L.;Tyrka, Audrey R.;Lee, Janet K.;Tracy, Aaron P.;Wilkinson, Charles W.;Price, Lawrence H.
地塞米松/促肾上腺皮质激素释放激素（Dex/CRH）测试是一种神经内分泌探针，涉及在标准化药理学挑战期间连续采集皮质醇血样，而不会引起人类心理困扰。过去的一些抑郁症患者的研究表明，在成功使用抗抑郁药治疗后，皮质醇对Dex/CRH测试的反应“正常化”或降低。对非抑郁症健康成年人样本的研究也表明，异常的皮质醇反应与抑郁症风险因素有关。这些发现促使研究使用Dex/CRH测试作为开发抗抑郁药物的工具。在本研究中，评价了Dex/CRH检测在非临床样本药物开发中的潜在效用。在22名健康成人（13名女性，9名男性）中，在使用舍曲林100 mg/天或匹配安慰剂进行盲法治疗6周之前和之后进行Dex/CRH试验。在控制年龄和性别后，与安慰剂相比，用标准剂量的舍曲林治疗后，皮质醇对Dex/CRH试验的反应增加。观察到的变化模式与已发表的抑郁症患者研究结果以及我们最初的假设形成对比。
The dexamethasone/corticotropin-releasing hormone (Dex/CRH) test is a neuroendocrine probe involving serial blood sampling of cortisol during a standardized pharmacological challenge without inducing psychological distress in humans. Some past studies in depressed patients have shown a “normalization” or decrease in cortisol response to the Dex/CRH test following successful treatment with an antidepressant. Studies in nondepressed healthy adult samples have also shown aberrant cortisol reactivity to be associated with depression risk factors. These findings prompted research into the use of the Dex/CRH test as a tool for developing antidepressant drugs. In this study, the Dex/CRH test was evaluated with regard to its potential utility for drug development in nonclinical samples. The Dex/CRH test was administered before and after 6 weeks of blinded treatment with either sertraline 100 mg/day or matching placebo in 22 healthy adults (13 women, nine men). Cortisol response to the Dex/CRH test increased following treatment with standard doses of sertraline, compared to placebo, after controlling for age and sex. The observed pattern of change contrasts with results from published studies in depressed patients and with our initial hypothesis.
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影响因子：
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