Water-soluble cationic gallium(III) and indium(III) phthalocyanines for photodynamic therapy
Water-soluble cationic gallium(III) and indium(III) phthalocyanines for photodynamic therapy
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DOI：
10.1016/j.jinorgbio.2009.12.011
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发表时间：
2010-03-01
影响因子：
3.9
通讯作者：
Ahsen, Vefa
中科院分区：
文献类型：
--
作者：
Durmus, Mahmut;Ahsen, Vefa
合成并表征了新型四元非周边和周边2-巯基吡啶取代的镓（III）和铟（III）酞菁配合物（np-GaPc，p-GaPc，np-InPc和p-InPc）及其季铵化衍生物（Qnp-GaPc，Qp-GaPc，Qnp-InPc和Qp-InPc）。季铵化配合物在水中具有良好的溶解性，这使得它们成为用于癌症光动力治疗（PDT）的潜在光敏剂。研究了这些酞菁化合物的光物理和光化学性质。总的趋势描述的量子产率的光降解，荧光和荧光寿命，以及这些化合物的单线态氧量子产率。在这项研究中，取代基的位置，金属离子的性质和取代基的季铵化对镓（III）和铟（III）酞菁的光物理和光化学参数的影响也报道。本研究还表明，离子型镓（III）和铟（III）酞菁强烈结合牛血清白蛋白（BSA）。(C)2009 Elsevier Inc. All rights reserved.
The new tetra-non-peripheral and peripheral 2-mercaptopyridine substituted gallium(III) and indium(III) phthalocyanine complexes (np-GaPc, p-GaPc, np-InPc and p-InPc) and their quaternized derivatives (Qnp-GaPc, Qp-GaPc, Qnp-InPc and Qp-InPc) have been synthesized and characterized. The quaternized complexes show excellent solubility in water, which makes them potential photorsensitizer for use in photodynamic therapy (PDT) of cancer. Photophysical and photochemical properties of these phthalocyanines were investigated. General trends are described for quantum yields of photodegradation, fluorescence and fluorescence lifetimes as well as singlet oxygen quantum yields of these compounds. In this study, the effects of the position of the substituents, the nature of the metal ion and quaternization of the substituents on the photophysical and photochemical parameters of the gallium(III) and indium(III) phthalocyanines are also reported. This study also presented the ionic gallium(III) and indium(III) phthalocyanines strongly bind to bovine serum albumin (BSA). (C) 2009 Elsevier Inc. All rights reserved.