PORTAL BLOOD FACTOR AS HUMORAL AGENT IN LIVER REGENERATION
PORTAL BLOOD FACTOR AS HUMORAL AGENT IN LIVER REGENERATION
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DOI：
10.1126/science.171.3971.575
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发表时间：
1971-01-01
期刊：
影响因子：
56.9
通讯作者：
FISHER, ER
中科院分区：
文献类型：
--
作者：
FISHER, B;SZUCH, P;FISHER, ER
通过使用体外交叉循环，证明了负责肝再生的体液因子不是来自肝残体。虽然正常大鼠的完整肝脏纳入[甲基-3H]胸苷的比例，在合作伙伴的肝脏切除量，最大的反应发生后，全肝切除术。从门腔静脉分流，部分肝切除的动物连接到正常成员的证据表明，该因子是在门静脉血和再生的开始是可用的门静脉血因子和肝细胞数量之间的定量失衡的结果。
It was demonstrated, by use of extracorporeal cross-circulation, that a humoral factor responsible for liver regeneration does not arise from the liver remnant. While intact livers of normal rats incorporated [methyl-3H]thymidine in proportion to the amount of liver removed in the partner, the greatest response occurred after a total hepatectomy. Evidence from portacaval-shunted, partially hepatectomized animals connected to normal members indicates that the factor is in portal blood and that the onset of regeneration is the result of a quantitative imbalance between the available portal blood factor and the number of liver cells present.