Multiple G-protein-coupled receptors mediate presynaptic inhibition at single excitatory synapses in the rat visual cortex
Multiple G-protein-coupled receptors mediate presynaptic inhibition at single excitatory synapses in the rat visual cortex
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DOI：
10.1016/s0304-3940(01)02051-1
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发表时间：
2001-08-24
影响因子：
2.5
通讯作者：
Tanabe, T
中科院分区：
文献类型：
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作者：
Murakoshi, T;Song, SY;Tanabe, T
在源自单个突触前神经元的内在皮质突触中研究了几种神经递质受体激动剂对兴奋性突触传递的调节。记录大鼠视觉皮层第 5 层锥体神经元对同一层内最小刺激的反应的兴奋性突触后电流 (EPSC)。 5-羟色胺、腺苷、巴氯芬、卡巴胆碱和 DCG-IV 均抑制 EPSC，并增加配对脉冲比。这些激动剂降低了微型 EPSC 的频率，但没有显着影响其振幅分布。这些结果表明，新皮质中的谷氨酸兴奋性传递受到突触前抑制的控制，该抑制是由在单个突触前末梢共表达的多种神经调节受体介导的。 (C) 2001 Elsevier Science Ireland Ltd. 保留所有权利。
Modulation of excitatory synaptic transmission by agonists for several neurotransmitter receptors was investigated at intrinsic cortical synapses derived from single presynaptic neurons. Excitatory postsynaptic currents (EPSCs) were recorded from layer 5 pyramidal neurons in the rat visual cortex in response to minimal stimulation within the same layer. 5-hydroxytryptamine, adenosine, baclofen, carbachol and DCG-IV all suppressed EPSCs with an increase in paired-pulse ratio. These agonists reduced the frequency of miniature EPSCs without significantly affecting their amplitude distribution. These results suggest that glutamatergic excitatory transmission in the neocortex is under the control of presynaptic inhibition mediated by multiple neuromodulator receptors co-expressed in single presynaptic terminals. (C) 2001 Elsevier Science Ireland Ltd. All rights reserved.