Contribution of sensory nerves to cutaneous reactive hyperaemia in non-Hispanic Black and White young adults.
Contribution of sensory nerves to cutaneous reactive hyperaemia in non-Hispanic Black and White young adults.
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感觉神经对非西班牙裔黑人和白人年轻人皮肤反应性充血的贡献。
DOI：
10.1113/ep091178
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发表时间：
2023
影响因子：
2.7
通讯作者：
Wong,BrettJ
中科院分区：
文献类型：
--
作者：
Turner,CaseyG;Walker,DemetriaC;Wong,BrettJ
这项研究的目的是评估非西班牙裔黑人和白人年轻人的皮肤感觉神经功能，不依赖于一氧化氮。我们测试了皮肤反应性充血和感觉神经介导的血管扩张在非西班牙裔黑人青年中比非西班牙裔白人青年低的假设。招募了24名自认为非西班牙裔黑人(n=12)或非西班牙裔白人(n=12)的参与者。所有参与者都经历了三次反应性充血。在对照部位和局部应用4%利多卡因抑制感觉神经功能的部位，使用激光多普勒血流仪连续测量皮肤血流指数。与非西班牙裔白人参与者相比，非西班牙裔黑人的反应性充血峰值较低(P<；0.001)。与非西班牙裔白人[对照组：6820(1179)%CVCmax；利诺卡因，3573(712%)%CVCmax]参与者相比，非西班牙裔黑人[平均(SD)；对照组，4085%(955%CVCmax；利诺卡因，2127(639%)%皮肤最大血管传导*秒，%CVCmax]参与者的总反应性充血发生率较低(P<；两个部位均为0.001)。在计算的感觉神经对峰值的贡献[非西班牙裔黑人，25(14)%；非西班牙裔白人，19(13)%]或总反应性充血反应[非西班牙裔黑人，48(10)%；非西班牙裔白人，47(10)%]方面，两组之间没有差异。这些数据表明，皮肤反应性充血在非西班牙裔黑人青年中较低，但感觉神经贡献在非西班牙裔黑人和白人青年中相似。
The aim of this study was to assess cutaneous sensory nerve function, independent of nitric oxide, in non‐Hispanic Black and White young adults. We tested the hypothesis that cutaneous reactive hyperaemia and sensory nerve‐mediated vasodilatation would be lower in non‐Hispanic Black young adults relative to non‐Hispanic White young adults. Twenty‐four participants who self‐identified as non‐Hispanic Black (n= 12) or non‐Hispanic White (n= 12) were recruited. All participants underwent three bouts of reactive hyperaemia. An index of skin blood flow was measured continuously using laser‐Doppler flowmetry at a control site and at a site treated with topical 4% lignocaine to inhibit sensory nerve function. Peak reactive hyperaemia was lower in non‐Hispanic Black relative to non‐Hispanic White participants (P< 0.001). Total reactive hyperaemia was lower in non‐Hispanic Black [mean (SD); control, 4085 (955)%CVCmaxs; lignocaine, 2127 (639) percent maximal cutaneous vascular conductance * seconds, %CVCmaxs] relative to non‐Hispanic White [control: 6820 (1179)%CVCmaxs; lignocaine, 3573 (712)%CVCmaxs] participants (P< 0.001 for both sites). There was no difference between groups for the calculated contribution of sensory nerves to either the peak [non‐Hispanic Black, 25 (14)%; non‐Hispanic White, 19 (13)%] or total reactive hyperaemic response [non‐Hispanic Black, 48 (10)%; non‐Hispanic White, 47 (10)%]. These data suggest that cutaneous reactive hyperaemia is lower in non‐Hispanic Black young adults, but the sensory nerve contribution is similar in non‐Hispanic Black and White young adults.