Elimination of schistosomiasis: the tools required.
Elimination of schistosomiasis: the tools required.
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DOI：
10.1186/s40249-017-0370-7
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发表时间：
2017-11-20
影响因子：
8.1
通讯作者：
Klohe K
中科院分区：
文献类型：
--
作者：
Bergquist R;Zhou XN;Rollinson D;Reinhard-Rupp J;Klohe K
从历史上看，血吸虫病控制的目标已经从感染转向发病，然后再回到感染，但现在作为一个公共卫生问题，然后再转向传播控制。目前，鼓励所有流行国家根据世界卫生组织（世卫组织）全球控制被忽视热带病路线图和世界卫生大会发布的WHA65.21决议的要求，加大控制努力，朝着消除热带病的方向迈进。然而，血吸虫病的流行率仍然高得惊人，由于纳入了一些以前未计算在内的“细微”临床症状，这种感染导致的全球残疾调整生命年（DALYs）实际上有所增加。有必要重新开始并加强努力，以实现消除目标。为此，全球血吸虫病联盟（GSA）研究工作组首次会议于2016年6月中旬在中华人民共和国上海举行。它审查了目前在血吸虫病控制和消除方面取得的进展，确定了需要解决的紧迫业务研究差距，并讨论了实现消除所需的新工具和战略。本次会议期间的演讲和讨论所产生的文章，连同一些额外的应邀论文，已被收集为《贫穷的传染病》的特刊，题为《血吸虫病研究：提供消除所需的工具》，共26篇论文。本文参考了这些论文，并讨论了会议上出现的与消除血吸虫病有关的关键问题。目前最紧迫的问题是：血吸虫病能被消灭吗？是否需要更好、更灵敏的诊断方法？在消除阶段预防性化疗的作用是什么？吡喹酮足够吗？还是我们需要新的药物？考虑到这些问题，人们认为世界流行地区的异质性要求世卫组织改进政策，制定新的、有区别的指导方针。本文的在线版本（doi: 10.1186/s40249-017-0370-7）包含补充材料，可供授权用户使用。
Historically, the target in the schistosomiasis control has shifted from infection to morbidity, then back to infection, but now as a public health problem, before moving on to transmission control. Currently, all endemic countries are encouraged to increase control efforts and move towards elimination as required by the World Health Organization (WHO) roadmap for the global control of the neglected tropical diseases (NTDs) and the WHA65.21 resolution issued by the World Health Assembly. However, schistosomiasis prevalence is still alarmingly high and the global number of disability-adjusted life years (DALYs) due to this infection has in fact increased due to inclusion of some ‘subtle’ clinical symptoms not previously counted. There is a need to restart and improve efforts to reach the elimination goal. To that end, the first conference of the Global Schistosomiasis Alliance (GSA) Research Working Group was held in mid-June 2016 in Shanghai, People’s Republic of China. It reviewed current progress in schistosomiasis control and elimination, identified pressing operational research gaps that need to be addressed and discussed new tools and strategies required to make elimination a reality. The articles emanating from the lectures and discussions during this meeting, together with some additional invited papers, have been collected as a special issue of the ‘Infectious Diseases of Poverty’ entitled ‘Schistosomiasis Research: Providing the Tools Needed for Elimination’, consisting of 26 papers in all. This paper refers to these papers and discusses critical questions arising at the conference related to elimination of schistosomiasis. The currently most burning questions are the following: Can schistosomiasis be eliminated? Does it require better, more highly sensitive diagnostics? What is the role of preventive chemotherapy at the elimination stage? Is praziquantel sufficient or do we need new drugs? Contemplating these questions, it is felt that the heterogeneity of the endemic areas in the world requires WHO policies to be upgraded instituting new, differentiated guidelines. The online version of this article (doi: 10.1186/s40249-017-0370-7) contains supplementary material, which is available to authorized users.
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影响因子：
8.1
作者：
Campbell SJ;Stothard JR;O'Halloran F;Sankey D;Durant T;Ombede DE;Chuinteu GD;Webster BL;Cunningham L;LaCourse EJ;Tchuem-Tchuenté LA
通讯作者：
Tchuem-Tchuenté LA
影响因子：
4
作者：
Gray, Darren J.;Li, Yue-Sheng;McManus, Donald P.
通讯作者：
McManus, Donald P.
影响因子：
3.8
作者：
Hotez PJ;Alvarado M;Basáñez MG;Bolliger I;Bourne R;Boussinesq M;Brooker SJ;Brown AS;Buckle G;Budke CM;Carabin H;Coffeng LE;Fèvre EM;Fürst T;Halasa YA;Jasrasaria R;Johns NE;Keiser J;King CH;Lozano R;Murdoch ME;O'Hanlon S;Pion SD;Pullan RL;Ramaiah KD;Roberts T;Shepard DS;Smith JL;Stolk WA;Undurraga EA;Utzinger J;Wang M;Murray CJ;Naghavi M
通讯作者：
Naghavi M
影响因子：
8.1
作者：
Balahbib A;Amarir F;Corstjens PL;de Dood CJ;van Dam GJ;Hajli A;Belhaddad M;El Mansouri B;Sadak A;Rhajaoui M;Adlaoui EB
通讯作者：
Adlaoui EB
影响因子：
2.7
作者：
Bergquist, Robert;Yang, Guo-Jing;Tanner, Marcel
通讯作者：
Tanner, Marcel