Role of matrix metalloproteinases in melanoma cell invasion
Role of matrix metalloproteinases in melanoma cell invasion
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DOI：
10.1016/j.biochi.2005.01.013
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发表时间：
2005-03-01
期刊：
影响因子：
3.9
通讯作者：
Becker, JC
中科院分区：
文献类型：
--
作者：
Hofmann, UB;Houben, R;Becker, JC
皮肤黑色素瘤是臭名昭著的倾向转移。该过程中的基本步骤是通过蛋白水解酶如基质金属蛋白酶（MMP）降解基底膜和重塑细胞外基质（ECM），所述蛋白水解酶由其组织抑制剂（TIMP）调节。NIMP表达不限于肿瘤细胞，也见于基质细胞，表明基质来源的蛋白酶可能促进黑色素瘤进展。MMPs已被证明与广泛的非基质蛋白相互作用，包括粘附分子、生长因子和血管生成和凋亡的介质。在这篇综述中，我们评估了新的见解的相互作用的基质金属蛋白酶和他们的分子合作伙伴在黑素瘤的进展。(c)2005年，Elsevier SAS。All rights reserved.
Cutaneous melanomas are notorious for their tendency to metastasize. Essential steps in this process are the degradation of basement membranes and remodeling of the extracellular matrix (ECM) by proteolytic enzymes such as matrix metalloproteinases (MMPs), which are regulated by their tissue inhibitors (TIMPs). An NIMP expression is not restricted to tumor cells but is also found in stromal cells, indicating that stroma-derived proteases may contribute to melanoma progression. The MMPs have been shown to interact with a broad range of non-matrix proteins including adhesion molecules, growth factors and mediators of angiogenesis and apoptosis. In this review, we evaluate new insights into the interplay of MMPs and their molecular partners in rnelanoma progression. (c) 2005 Elsevier SAS. All rights reserved.