Regional skeletal muscle measurement: evaluation of new dual-energy X-ray absorptiometry model
Regional skeletal muscle measurement: evaluation of new dual-energy X-ray absorptiometry model
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DOI：
10.1152/jappl.1999.87.3.1163
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发表时间：
1999-09-01
影响因子：
3.3
通讯作者：
Heymsfield, SB
中科院分区：
文献类型：
--
作者：
Wang, W;Wang, ZM;Heymsfield, SB
尽管人们对研究肌肉分布越来越感兴趣，但区域骨骼肌 (SM) 质量测量方法仍然有限。本研究的目的是开发一种新的双能 X 射线吸收测定法 (DEXA) 模型，用于估计区域无脂肪组织骨骼肌质量 (AT-free SM)。组织系统级成分（即无 AT SM、AT、骨骼和皮肤）与分子级成分（包括无脂肪软组织、脂肪和骨矿物质）之间的关系源自 Reference Man 数据。所提出的 DEXA-SM 模型通过多重扫描计算机轴向断层扫描 (CT) 进行评估。 27 名男性受试者[年龄，36 +/- 12 (SD) 岁；体重，73.2 +/- 12.4 千克； 20 人健康，7 人患有获得性免疫缺陷综合征]完成了 DEXA。和 CT 研究。在三个区域选择相同的 DEXA 和 CT 测量标志，包括小腿、大腿和前臂。新的 DEXA 和 CT 方法之间的无 AT SM 估计值具有很强的相关性（例如，三个区域的总和，r = 0.86，P < 0.001）。通过DEXA和CT测量的27名受试者的区域无AT SM分别为3.44 +/- 0.60和3.47 +/- 0.55 kg（差异0.9%，P > 0.05），犊牛为10.49 +/- 1.77和10.05 +/- 1.79 kg（差异4.4%，P < 0.05）大腿：1.36 +/- 0.49 和 1.20 +/- 0.41 前臂的重量为 15.29 +/- 2.33 和 14.72 +/- 2.33 公斤（差异 13.3%，P < 0.01），所有三个区域的总和为 15.29 +/- 2.33 和 14.72 +/- 2.33 公斤（差异 3.9%，P < 0.05）。尽管建议的 DEXA-SM 模型需要进行细微的改进，但这是一种用于测量区域 SM 的有前途的体内方法，因为 DEXA 广泛可用，相对便宜，并且辐射暴露较低。
Although there is growing interest in studying muscle distribution, regional skeletal muscle (SM) mass measurement methods remain limited. The aim of the present study was to develop a new dual-energy X-ray absorptiometry (DEXA) model for estimating regional adipose tissue-free skeletal muscle mass (AT-free SM). Relationships were derived from Reference Man data between tissue-system-level components (i.e.,AT-free SM, AT, skeleton, and skin) and molecular-level components including fat-free soft tissue, fat, and bone mineral. The proposed DEXA-SM model was evaluated by multiscan computerized axial tomography (CT). Twenty-seven male subjects [age, 36 +/- 12 (SD) yr; body mass, 73.2 +/- 12.4 kg; 20 were healthy, and 7 had acquired immunodeficiency syndrome] completed DEXA. and CT studies. Identical landmarks for DEXA and CT measurements were selected in three regions, including calves, thighs, and forearms. There was a strong correlation for AT-free SM estimates between the new DEXA and CT methods (e.g., sum of three regions, r = 0.86, P < 0.001). RegionalAT-free SM measured in the 27 subjects by DEXA and CT, respectively, were 3.44 +/- 0.60 and 3.47 +/- 0.55 kg (difference 0.9%, P > 0.05) for calves, 10.49 +/- 1.77 and 10.05 +/- 1.79 kg (difference 4.4%, P < 0.05) for thighs, 1.36 +/- 0.49 and 1.20 +/- 0.41 kg (difference 13.3%, P < 0.01) for forearms, and 15.29 +/- 2.33 and 14.72 +/- 2.33 kg (difference 3.9%, P < 0.05) for the sum all three regions. Although the suggested DEXA-SM model needs minor refinements, this is a promising in vivo approach for measurement of regional SM, because DEXA is widely available, relatively inexpensive, and radiation exposure is low.