Drug delivery systems
Drug delivery systems
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DOI：
10.1179/030801800679206
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发表时间：
2000-09-01
影响因子：
1.1
通讯作者：
Davis, SS
中科院分区：
文献类型：
--
作者：
Davis, SS
药物递送系统在药物、疫苗和诊断剂的施用中发挥重要作用。基于生物可降解聚合物的系统可特别有利地用作提供缓慢、稳定释放药理学试剂的植入物。材料包括聚-α-羟基酸、聚酸酐和聚磷腈。以肽和蛋白质形式存在的生物技术产品是难以递送的具有挑战性的化合物。新的递送方法包括聚合物微球和微胶囊。聚合物可用于递送抗原，以便在注射后获得改善的应答。基于聚合物材料的纳米颗粒可用于将药物递送到特定的靶位点，特别是通过血流或淋巴系统。天然聚合物在药物递送中也具有重要作用，例如壳聚糖因其与粘膜表面相互作用并提供将药物保留在靶位点的生物粘附作用的能力而受到特别关注。
Drug delivery systems have an important role to play in the administration of drugs, vaccines, and diagnostic agents. Systems based on biodegradable polymers can be especially advantageous for use as implants that provide a slow, steady release of a pharmacological agent. Materials include poly-a-hydroxy acids, polyanhydrides, and polyphosphazenes. The products of biotechnology in the form of peptides and proteins are challenging compounds that are difficult to deliver. Novel methods of delivery include polymeric microspheres and microcapsules. Polymers can be used to deliver antigens in order to obtain improved responses after injection. Nanoparticles based on polymeric materials can be employed to deliver drugs to specific target sites, especially via the bloodstream or lymphatic system. Natural polymers also have an important role in drug delivery, for example chitosan is of special interest for its ability to interact with mucosal surfaces and to provide a bioadhesive effect that will retain drugs at target sites.