The role of dysfunctional HDL in atherosclerosis
The role of dysfunctional HDL in atherosclerosis
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DOI：
10.1194/jlr.r800036-jlr200
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发表时间：
2009-04-01
影响因子：
6.5
通讯作者：
Fogelman, Alan M.
中科院分区：
文献类型：
--
作者：
Navab, Mohamad;Reddy, Srinivasa T.;Fogelman, Alan M.
本文综述了HDL在调节LDL氧化和LDL诱导的炎症中的作用。在动物模型和患有慢性炎性疾病（包括动脉粥样硬化）的人中已发现HDL功能障碍。在动物模型中，也许在人类中，功能失调的HDL可以通过以高亲和力结合氧化脂质的apoA-I模拟肽来改善。Navab，M.，S. T.雷迪，B。J.货车伦滕，G. M. Anantharamaiah和A. M.福格尔曼功能失调的HDL在动脉粥样硬化中的作用。J. Lipid Res. 2009. S145-S149。
This review focuses on HDL function in modulating LDL oxidation and LDL-induced inflammation. Dysfunctional HDL has been identified in animal models and humans with chronic inflammatory diseases including atherosclerosis. The loss of antiinflammatory function correlated with a loss of function in reverse cholesterol transport.jlr In animal models and perhaps in humans, dysfunctional HDL can be improved by apoA-I mimetic peptides that bind oxidized lipids with high affinity.-Navab, M., S. T. Reddy, B. J. Van Lenten, G. M. Anantharamaiah, and A. M. Fogelman. The role of dysfunctional HDL in atherosclerosis. J. Lipid Res. 2009. S145-S149.