Collision tumor of anaplastic oligodendroglioma and gangliocytoma: a case report
Collision tumor of anaplastic oligodendroglioma and gangliocytoma: a case report
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DOI：
10.1007/s10014-009-0255-y
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发表时间：
2009-10-01
影响因子：
3.3
通讯作者：
Tominaga, Teiji
中科院分区：
文献类型：
--
作者：
Takeuchi, Yoichi;Kanamori, Masayuki;Tominaga, Teiji
一名 53 岁女性出现罕见的间变性少突胶质细胞瘤与神经节细胞瘤共存的病例，表现为进行性意识障碍和左侧偏瘫。钆磁共振成像显示，肿块病变由大脑中动脉周围的强增强区域和右颞叶、岛叶和基底神经节的弱增强区域组成。她接受了肿瘤次全切除术，症状得到改善。宏观和组织学检查显示肿瘤由两种不同的成分组成：灰色软组织和黄色硬组织。前者由大小相等的圆形至椭圆形深染细胞核和核周晕组成，微血管增生和坏死，诊断为间变性少突胶质细胞瘤。后者由大且发育不良的神经元组成，具有明显的核仁和含有尼氏体的嗜碱性细胞质，间质中有非肿瘤性胶质细胞，诊断为神经节细胞瘤。两个病变都是明显的，但在边界处混合在一起。这两个肿瘤显然是作为碰撞肿瘤发生的。
A 53-year-old woman presented with a rare case of coexistence of anaplastic oligodendroglioma with gangliocytoma manifesting as progressive disturbance of consciousness and left hemiparesis. Magnetic resonance imaging with gadolinium demonstrated the mass lesion consisted of a strongly enhanced area around the middle cerebral artery and less enhanced areas in the right temporal lobe, insula, and basal ganglia. She underwent subtotal resection of the tumor, resulting in improvement of her symptoms. Macroscopic and histological examination showed the tumor consisted of two distinct components, grayish soft tissue and yellowish hard tissue. The former consisted of cells with equal-sized round-to-oval hyperchromatic nuclei and perinuclear halo with microvascular proliferation and necrosis, and the diagnosis was anaplastic oligodendroglioma. The latter consisted of large and dysplastic neurons with marked nucleoli and basophilic cytoplasm containing Nissl bodies, with nonneoplastic glial cells in the stroma, and the diagnosis was gangliocytoma. Both lesions were distinct, but intermingled at the border. These two tumors apparently occurred as a collision tumor.