Mechanisms of immune regulation at mucosal surfaces.
Mechanisms of immune regulation at mucosal surfaces.
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粘膜表面的免疫调节机制。
DOI：
10.1093/clinids/5.supplement_4.s784
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发表时间：
1983
期刊：
影响因子：
--
通讯作者：
TomasiJr,TB
中科院分区：
文献类型：
--
作者：
TomasiJr,TB
本文就粘膜表面免疫的三个方面作一综述。首先是粘膜表面对IgA合成的承诺的起源，以及同型特异性调节性T细胞在这一过程中的可能作用。在分子生物学最新发展的背景下，即T细胞通过提供特定的IgA重组酶来调节转换的可能性，讨论了T细胞在从原始的、携带IgM的细胞向产生抗原敏感的IgA产生的B细胞转换中的作用。其次，回顾了细胞从肠粘膜到其他粘膜部位的迁移模式，并提供了证实T细胞和B细胞迁移的新数据。第三，讨论了口服耐受性的概念，并对肠道免疫后伴随的分泌性免疫和全身耐受性发展的意义进行了综述。新的数据表明，尽管口服免疫后存在抑制细胞，但预先使用环磷酰胺和秋水仙碱等药物来消除脾T抑制细胞，并不影响口服耐受的诱导。
This review focuses on three aspects of immunity at mucosal surfaces. The first is the origin of the commitment of mucosal surfaces to IgA synthesis and the possible role of isotype-specific regulatory T cells in this process. The role of T cells in switching from virgin, IgM-bearing cells to antigen-sensitive IgA-producing B cells is discussed in the context of recent developments in molecular biology, i.e., the possibility that the T cell regulates switching by providing a specific IgA recombinase. Second, the migratory patterns of cells from the gut mucosa to other mucosal sites are reviewed, and new data substantiating the migration of T cells in addition to B cells are presented. Third, the concept of oral tolerance is discussed, and the implications of the concomitant development of secretory immunity and systemic tolerance following enteric immunization are reviewed. New data are presented that suggest that although suppressor cells are present following oral immunization, prior treatment with agents such as cytoxan and colchicine, which eliminate splenic T suppressor cells, does not influence the induction of oral tolerance.