Lipid Droplets in Cancer: Guardians of Fat in a Stressful World.
Lipid Droplets in Cancer: Guardians of Fat in a Stressful World.
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癌症中的脂质液滴：压力大的世界中的脂肪监护人。
DOI：
10.3390/molecules23081941
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发表时间：
2018-08-03
期刊：
影响因子：
--
通讯作者：
Jusović M
中科院分区：
文献类型：
--
作者：
Petan T;Jarc E;Jusović M
癌细胞具有适应不利环境条件的非凡能力。它们在严重营养和氧化应激期间的存活取决于它们获得细胞外脂质的能力以及它们的细胞内脂质合成、动员和再循环机制的可塑性。脂滴是存在于从酵母到人类的大多数细胞中的细胞溶质脂肪储存细胞器，正在成为暴露于压力的各种细胞和组织中脂质代谢、运输和信号传导的主要调节剂。它们的生物合成是由营养和氧化应激诱导的，并且它们在各种癌症中积累。脂滴充当开关，其协调细胞中用于不同目的的脂质运输和消耗，例如能量产生、保护免受氧化应激或细胞快速生长期间的膜生物发生。它们隔离有毒脂质，如脂肪酸、胆固醇和神经酰胺，从而防止脂毒性细胞损伤，并与自噬有复杂的关系。在这里，我们专注于应激诱导的脂滴生物发生的新兴机制;它们在营养，脂毒性和氧化应激过程中的作用;以及脂滴和自噬之间的关系。最近发现的脂滴生物学原理可以提高我们对癌细胞适应性和应激恢复机制的理解。
Cancer cells possess remarkable abilities to adapt to adverse environmental conditions. Their survival during severe nutrient and oxidative stress depends on their capacity to acquire extracellular lipids and the plasticity of their mechanisms for intracellular lipid synthesis, mobilisation, and recycling. Lipid droplets, cytosolic fat storage organelles present in most cells from yeast to men, are emerging as major regulators of lipid metabolism, trafficking, and signalling in various cells and tissues exposed to stress. Their biogenesis is induced by nutrient and oxidative stress and they accumulate in various cancers. Lipid droplets act as switches that coordinate lipid trafficking and consumption for different purposes in the cell, such as energy production, protection against oxidative stress or membrane biogenesis during rapid cell growth. They sequester toxic lipids, such as fatty acids, cholesterol and ceramides, thereby preventing lipotoxic cell damage and engage in a complex relationship with autophagy. Here, we focus on the emerging mechanisms of stress-induced lipid droplet biogenesis; their roles during nutrient, lipotoxic, and oxidative stress; and the relationship between lipid droplets and autophagy. The recently discovered principles of lipid droplet biology can improve our understanding of the mechanisms that govern cancer cell adaptability and resilience to stress.
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影响因子：
5.9
作者：
Balaban S;Shearer RF;Lee LS;van Geldermalsen M;Schreuder M;Shtein HC;Cairns R;Thomas KC;Fazakerley DJ;Grewal T;Holst J;Saunders DN;Hoy AJ
通讯作者：
Hoy AJ
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19
作者：
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通讯作者：
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4
作者：
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通讯作者：
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影响因子：
64.5
作者：
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通讯作者：
Gould AP
影响因子：
64.8
作者：
Bernardi, Rosa;Guernah, Ilhem;Pandolfi, Pier Paolo
通讯作者：
Pandolfi, Pier Paolo