G = E: What GWAS Can Tell Us about the Environment.
G = E: What GWAS Can Tell Us about the Environment.
复制标题
DOI：
10.1371/journal.pgen.1005765
复制
发表时间：
2016-02
期刊：
影响因子：
4.5
通讯作者：
Munafò MR
中科院分区：
文献类型：
--
作者：
Gage SH;Davey Smith G;Ware JJ;Flint J;Munafò MR
随着我们对遗传学的理解不断提高，全基因组关联研究（GWAS）已经确定了许多与生活方式行为和健康结果相关的变异。然而，有时被忽视的是，在疾病的GWAS中发现的遗传变异可能反映了可改变的风险因素以及直接遗传效应的影响。我们讨论了这种可能性与说明性的例子，从烟草和酒精的研究，其中预测行为表型的遗传变异已被视为在GWAS的疾病已知的因果关系，这些行为。这种考虑对GWAS结果的解释有影响。
As our understanding of genetics has improved, genome-wide association studies (GWAS) have identified numerous variants associated with lifestyle behaviours and health outcomes. However, what is sometimes overlooked is the possibility that genetic variants identified in GWAS of disease might reflect the effect of modifiable risk factors as well as direct genetic effects. We discuss this possibility with illustrative examples from tobacco and alcohol research, in which genetic variants that predict behavioural phenotypes have been seen in GWAS of diseases known to be causally related to these behaviours. This consideration has implications for the interpretation of GWAS findings.