Gelatinases (MMP-2 and MMP-9) are preferentially expressed by Th1 vs. Th2 cells
Gelatinases (MMP-2 and MMP-9) are preferentially expressed by Th1 vs. Th2 cells
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DOI：
10.1016/j.jneuroim.2005.02.001
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发表时间：
2005-06-01
影响因子：
3.3
通讯作者：
Miller, A
中科院分区：
文献类型：
--
作者：
Abraham, M;Shapiro, S;Miller, A
辅助 T 细胞亚群 Th1 和 Th2 与不同类型的免疫反应相关，其细胞因子谱和不同趋化因子受体的表达有所不同，这可能会对其迁移能力产生不同的影响。本研究检测了两种 CD4(+) Th 细胞亚群的基质金属蛋白酶 (MMP)-2 和 MMP-9 的表达以及这些蛋白酶在其迁移中的作用。我们观察到CD4(+)T细胞的迁移依赖于明胶酶，并且Th1细胞的迁移能力高于Th2细胞。此外，与来自人类(健康受试者和多发性硬化症(MS)患者)以及来自小鼠来源的Th2细胞相比，Th1细胞分泌更高水平的MMP-2和MMP-9。这些新发现有助于理解生理性 Th I 和 Th2 免疫反应以及免疫介导疾病（例如 MS）中增强的 Th I 反应性，其中 MMP-2 和 MMP-9 水平的增强与疾病过程相关。 (C) 2005 Elsevier B.V. 保留所有权利。
T helper subsets, Th1 and Th2, which are associated with different types of immune reactions, are distinguished by their cytokines' profiles and expression of different chemokine receptors, that may differentially influence their migratory capacity. The present study examined the expression of matrix metalloproteinases, (MMP)-2 and MMP-9, by the two CD4(+) Th cell subsets and the role of these proteases in their migration. We observed that migration of CD4(+) T cells is dependent on the gelatinases, and that the migratory capacity of Th1 is higher than Th2 cells. In addition, Th I in comparison to Th2 cells, from both human (healthy subjects and multiple sclerosis (MS) patients) as well as from murine origin, secrete higher levels of MMP-2 and MMP-9. These novel findings contribute to the understanding of the physiological Th I and Th2 immune responses as well as the enhanced Th I reactivity in immune-mediated diseases, such as MS, in which enhanced levels of MMP-2 and MMP-9 are associated with disease processes. (C) 2005 Elsevier B.V. All rights reserved.